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Gene Review

FOXJ1  -  forkhead box J1

Homo sapiens

Synonyms: FKHL13, Forkhead box protein J1, Forkhead-related protein FKHL13, HFH-4, HFH4, ...
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Disease relevance of FOXJ1


High impact information on FOXJ1

  • Thus, Foxd1 modulates inflammatory reactions and prevents autoimmunity by directly regulating anti-inflammatory regulators of the NF-AT pathway, and by coordinating the suppression of the NF-kappaB pathway via Foxj1 [5].
  • Expression of fluorescently tagged cAMP-dependent kinase subunits from the ciliated-cell-specific foxj1 promoter enhanced expression in fully differentiated ciliated human airway epithelial cells, and permitted simultaneous measurements of ciliary beat frequency and cAMP (represented by the FRET ratio) [6].
  • To develop a ciliated cell-specific promoter for CF gene therapy, we have characterized the promoter region of the FOXJ1 gene, a transcription factor required for ciliated cell differentiation [7].
  • Our results demonstrate that elements within the FOXJ1 promoter region are sufficient to target expression of transgenes to ciliated cells and may be useful for gene therapy of CF [7].
  • Significantly, gene expression associated with ciliogenesis is evident in bronchial epithelium, and includes the expression of transcripts specifying axonemal proteins DNAI2, SPAG6, ASP, and FOXJ1 transcription factor [8].

Biological context of FOXJ1


Anatomical context of FOXJ1


Associations of FOXJ1 with chemical compounds


Other interactions of FOXJ1

  • Our results suggest that the SNPs g.-460C>T, g.1805G>T and g.3375G>C in the human FOXJ1 gene might be associated with susceptibility to allergic rhinitis (P=0.0184, 0.0076, and 0.0143, respectively) [1].
  • Class 1 regulators include the autoinhibitory domain of the phosphatase calcineurin; IkappaB and its transcriptional activators Foxj1 and Foxo3a; and various transcriptional coregulators that inhibit interleukin-2 (IL-2) production [12].
  • Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate (S1P), transcription factors such as Foxj1, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc [13].
  • Recently, several forkhead genes have been demonstrated to play critical roles in lymphocyte development and effector function, including Foxp3 in the development of regulatory T cells, Foxj1 and Foxo3a in the regulation of CD4+ T cell tolerance, and Foxn1 in thymic development [14].

Analytical, diagnostic and therapeutic context of FOXJ1


  1. Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis. Li, C.S., Chae, S.C., Lee, J.H., Zhang, Q., Chung, H.T. J. Hum. Genet. (2006) [Pubmed]
  2. No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD). Maiti, A.K., Bartoloni, L., Mitchison, H.M., Meeks, M., Chung, E., Spiden, S., Gehrig, C., Rossier, C., DeLozier-Blanchet, C.D., Blouin, J., Gardiner, R.M., Antonarakis, S.E. Cytogenet. Cell Genet. (2000) [Pubmed]
  3. Aberrant expression of TTF-1 and forkhead factor HFH-4 in atrophic gastritis and ciliated metaplasia suggests gastric broncho-pulmonary transdetermination. Rau, T., Dimmler, A., Häfner, M., Brabletz, T., Kirchner, T., Faller, G. J. Pathol. (2005) [Pubmed]
  4. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Missiaglia, E., Blaveri, E., Terris, B., Wang, Y.H., Costello, E., Neoptolemos, J.P., Crnogorac-Jurcevic, T., Lemoine, N.R. Int. J. Cancer (2004) [Pubmed]
  5. Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. Lin, L., Peng, S.L. J. Immunol. (2006) [Pubmed]
  6. Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells. Schmid, A., Bai, G., Schmid, N., Zaccolo, M., Ostrowski, L.E., Conner, G.E., Fregien, N., Salathe, M. J. Cell. Sci. (2006) [Pubmed]
  7. Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter. Ostrowski, L.E., Hutchins, J.R., Zakel, K., O'Neal, W.K. Mol. Ther. (2003) [Pubmed]
  8. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan, K.M., Chari, R., Deleeuw, R.J., Shadeo, A., Chi, B., Tsao, M.S., Jones, S., Marra, M., Ling, V., Ng, R., Macaulay, C., Lam, S., Lam, W.L. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  9. The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression. Murphy, D.B., Seemann, S., Wiese, S., Kirschner, R., Grzeschik, K.H., Thies, U. Genomics (1997) [Pubmed]
  10. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Pelletier, G.J., Brody, S.L., Liapis, H., White, R.A., Hackett, B.P. Am. J. Physiol. (1998) [Pubmed]
  11. Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct. Okada, A., Ohta, Y., Brody, S.L., Watanabe, H., Krust, A., Chambon, P., Iguchi, T. J. Mol. Endocrinol. (2004) [Pubmed]
  12. The yins of T cell activation. Liu, J.O. Sci. STKE (2005) [Pubmed]
  13. Thymic output: influence factors and molecular mechanism. Jin, R., Zhang, J., Chen, W.F. Cell. Mol. Immunol. (2006) [Pubmed]
  14. Forkhead transcription factors in immunology. Jonsson, H., Peng, S.L. Cell. Mol. Life Sci. (2005) [Pubmed]
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