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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A smart magnetic resonance contrast agent for selective copper sensing.

We describe the synthesis and properties of Copper-Gad-1 ( CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ over abundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.[1]


  1. A smart magnetic resonance contrast agent for selective copper sensing. Que, E.L., Chang, C.J. J. Am. Chem. Soc. (2006) [Pubmed]
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