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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Siah-1 facilitates ubiquitination and degradation of factor inhibiting HIF-1alpha (FIH).

Hypoxia-inducible factor-1alpha (HIF-1alpha) has a central role in neuroprotective responses to hypoxia in the brain. Hydroxylation of HIF-1alpha by prolyl-hydroxylase PHD and aspargynyl-hydroxylase FIH (factor inhibiting HIF-1alpha) causes proteasomal degradation and transcriptional inhibition of HIF-1alpha. Siah ubiquitin ligases regulate the abundance of PHD via targeting for proteasomal degradation. The present study identified Siah-1 as a binding partner for another hydroxylase FIH. Siah-1 and FIH coimmunoprecipitated each other in mammalian cells. Siah-1 was found both to interact with the JmjC domain of FIH through its substrate-binding domain and to specifically ubiquitinate FIH via its RING finger domain. Siah-1 facilitated FIH degradation via the ubiquitin-proteasome pathway under hypoxic conditions. Such findings suggest that Siah ubiquitin ligases might play a role as up-stream regulators of both hydroxylases for HIF-1alpha, i.e., PHD and FIH, by targeting them for proteasomal degradation, leading to increased HIF-1alpha abundance, and transcriptional activity in hypoxia.[1]


  1. Siah-1 facilitates ubiquitination and degradation of factor inhibiting HIF-1alpha (FIH). Fukuba, H., Yamashita, H., Nagano, Y., Jin, H.G., Hiji, M., Ohtsuki, T., Takahashi, T., Kohriyama, T., Matsumoto, M. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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