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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model.

PURPOSE: To determine the usefulness of slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing tranilast, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-tranilast group (group P-T), the PTFE group (group P), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye 3 or 5 weeks after surgery. In group P, adjustment was possible in 5 of 8 eyes 3 weeks after surgery and in 5 of 10 eyes 5 weeks after surgery. In group P-T, adjustment was possible in 8 of 10 eyes 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group P-T and the control group 3 and 5 weeks after surgery (P = 0.006, P = 0.006, respectively). A significant difference was observed between group P-T and the control group (P = 0.016) in terms of adhesion between SRMs and conjunctivae 5 weeks after surgery. CONCLUSIONS: Slow-releasing tranilast in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.[1]

References

  1. Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model. Lee, M.J., Jin, S.E., Kim, C.K., Choung, H.K., Jeoung, J.W., Kim, H.J., Choe, G., Hwang, J.M. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
 
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