The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Strabismus

  • The results of this study raise the possibility that diltiazem may be used as an alternative to the surgical treatment of strabismus and other oculomotor dysfunctions including blepharospasm [1].
  • PURPOSE: To examine baseline measurements of accommodative lag, phoria, reading distance, amount of near work, and level of myopia as risk factors for progression of myopia and their interaction with treatment over 3 years, in children enrolled in the Correction of Myopia Evaluation Trial (COMET) [2].
  • A new monoclonal antibody to the NMDA receptor subunit 1 (NMDA-R1) has been used to localize and compare the distribution of the receptors in the primary visual cortex of normal cats and those raised with either amblyopia induced by monocular optical blur or monocular esotropic strabismus [3].
  • Apart from a small increase (mean, 2 prism dipoters; p = 0.004) in their exophoria at near, normal subjects exhibited no significant change in their phorias after Tensilon injection [4].
  • When further surgery is planned after retinal detachment cyclodiathermy or strabismus operations, fluorescein angiography is a useful indicator of the vascular status of the iris and hence of the possibility of necrosis of the anterior segment [5].

High impact information on Strabismus


Chemical compound and disease context of Strabismus

  • Hydroxypropylmethylcellulose and sodium hyaluronate in adjustable strabismus surgery [10].
  • AIM: To present our experience with single-stage adjustable strabismus surgery (SSASS) under topical anesthesia and propofol [11].
  • RESULTS: Release of the IOI muscle reduced the ipsilateral vertical deviation an average of 3.5 PD ( P > 0.001) in cases of hypotropia and 5.8 PD ( P > 0.001) in patients with hypertropia, with stability of alignment for a minimum of 2 years [12].
  • Experimental strabismus surgery using N-butyl-2-cyanoacrylate (Histoacryl) [13].
  • PURPOSE: To determine a way to prevent the formation of adhesions and delay the time of suture adjustment in the course of adjustable strabismus surgery, an animal study was performed to assess and compare the effects of mitomycin C (Mit-C) and viscoelastic material Viscoat (sodium hyaluronate 3% and chondroitin sulphate 4%, Alcon, Fort Worth, TX) [14].

Gene context of Strabismus

  • We used (24 h) occlusion and associated phoria measurements (Part II) to determine vertical prism prescriptions which eliminated symptoms of seven symptomatic patients who did not show significant vertical heterophoria on routine clinical testing [15].
  • Even though the mean reduction of hypertropia in adduction in the ATIO group (mean: 27.7 +/- 9.6 Delta) was greater than in the DIO group (mean: 20.6 +/- 6.2 Delta), no statistically significant difference was found (p = 0.067) [16].
  • Before and after each of the two work sessions far refraction, far phorias, near point of accommodation (APP), and fusional convergence were measured [17].
  • RESULTS: The phorias obtained from these six methods were not significantly different from each other (repeated measures anova, p > 0.05) [18].
  • CONCLUSION: Scar formation hindering anteroposterior travel of the IR pulley system is a novel mechanism of restrictive hypertropia in infraduction following lower eyelid surgery [19].

Analytical, diagnostic and therapeutic context of Strabismus


  1. Diltiazem reduces the contractility of extraocular muscles in vitro and in vivo. Jacoby, J., Kahn, D.N., Pavlica, M.R., Ko, K., Breinin, G.M. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  2. Accommodation and related risk factors associated with myopia progression and their interaction with treatment in COMET children. Gwiazda, J.E., Hyman, L., Norton, T.T., Hussein, M.E., Marsh-Tootle, W., Manny, R., Wang, Y., Everett, D. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Distribution and localization of NMDA receptor subunit 1 in the visual cortex of strabismic and anisometropic amblyopic cats. Yin, Z.Q., Crewther, S.G., Yang, M., Crewther, D.P. Neuroreport (1996) [Pubmed]
  4. The effect of edrophonium chloride on muscle balance in normal subjects and those with nonmyasthenic strabismus. Siatkowski, R.M., Shah, L., Feuer, W.J. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. (1997) [Pubmed]
  5. Provoked iris ischaemia in the rabbit: A fluorescien angiographic study. Kottow, M., Wassilewa, P., Hendrickson, P. Can. J. Ophthalmol. (1975) [Pubmed]
  6. Neurology of latent nystagmus. Gresty, M.A., Metcalfe, T., Timms, C., Elston, J., Lee, J., Liu, C. Brain (1992) [Pubmed]
  7. Use of polyurethane with sustained release dexamethasone in delayed adjustable strabismus surgery. Kim, J.H., Jeong, S.Y., Jung, M.H., Hwang, J.M. The British journal of ophthalmology. (2004) [Pubmed]
  8. Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery. Hwang, J.M., Chang, B.L. The British journal of ophthalmology. (1999) [Pubmed]
  9. Use of physical barriers for delayed adjustable strabismus surgery: the effect of interceed and polyglactin 910 mesh. Hwang, J.M., Chang, B.L. The British journal of ophthalmology. (1996) [Pubmed]
  10. Hydroxypropylmethylcellulose and sodium hyaluronate in adjustable strabismus surgery. Ferreira, R.C., Lamberts, M., Moreira, J.B., Campos, M.S. Journal of pediatric ophthalmology and strabismus. (1995) [Pubmed]
  11. Single-stage adjustable strabismus surgery under topical anesthesia and propofol. Koc, F., Durlu, N., Ozal, H., Yasar, H., Firat, E. Strabismus (2005) [Pubmed]
  12. Vertical deviations improved with release of postoperative inferior oblique muscle inclusion. Cline, R., Valenzuela, A., Sketchley, M. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2005) [Pubmed]
  13. Experimental strabismus surgery using N-butyl-2-cyanoacrylate (Histoacryl). Jung, Y.C., Chang, B.L. Korean journal of ophthalmology : KJO. (1988) [Pubmed]
  14. Comparison of the effectiveness of mitomycin-C and Viscoat on delayed adjustable strabismus surgery in rabbits. Cengiz, Y., Altintas, O., Manav Ay, G., Cağlar, Y. European journal of ophthalmology. (2005) [Pubmed]
  15. Diagnostic occlusion and clinical management of latent hyperphoria. Surdacki, M., Wick, B. Optometry and vision science : official publication of the American Academy of Optometry. (1991) [Pubmed]
  16. A comparative study of the effectiveness of disinsertion and anterior transposition of the inferior oblique in the treatment of unilateral superior oblique palsy. Yanyali, A., Elibol, O., Talu, H., Karabas, L., Alp, B., Caglar, Y. Strabismus (2001) [Pubmed]
  17. Viewing distance variation and related ophthalmological changes in office activities with and without VDUs. Piccoli, B., Braga, M., Zambelli, P.L., Bergamaschi, A. Ergonomics. (1996) [Pubmed]
  18. Comparison of near heterophoria tests under varying conditions on an adult sample. Lam, A.K., Lam, A., Charm, J., Wong, K.M. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (2005) [Pubmed]
  19. Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. Pirouzian, A., Goldberg, R.A., Demer, J.L. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2004) [Pubmed]
  20. Experimental suture studies in strabismus surgery. II. Comparison of tensile strength of plain catgut with polyglycolic acid (Dexon) sutures after extraocular muscle surgery. Apt, L., Gaffney, W.L., Dora, A.F. Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology. (1976) [Pubmed]
  21. Reduction of postoperative adhesions in strabismus surgery. Oh, S.O., Lee, J. Korean journal of ophthalmology : KJO. (1992) [Pubmed]
WikiGenes - Universities