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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phenanthroline-derived ratiometric chemosensor for ureas.

The syntheses of 1,10-phenanthroline fluorophore-based chemosensor 7 and its truncated analog 9 are reported. Interactions of these compounds with urea, thiourea, 1,3-dimethylurea, tetrahydropyrimidin-2(1H)-one, imidazolidin-2-one, and selected uronium salts were assessed by three-dimensional excitation-emission spectroscopy, UV-vis absorbance, and fluorescence titrations. Chemosensor 7 was found to be capable of distinguishing between neutral ureas and their salts, by producing a different optical response for each type of compounds. The complexation of urea by 7 was also studied by selective-NOE 1H NMR, 13C NMR (using 13C-labeled guest), and MALDI-TOF mass spectrometry. In addition, we performed DFT calculations (B3LYP 3-21g** level) for structures of complexes of 7 with urea, imidazolidin-2-one, and tetrahydropyrimidin-2(1H)-one. Development of chemosensor 7-type compounds in conjunction with differential excitation-emission spectroscopy represents an important step toward the development of novel tools for ureas and their salts analysis.[1]


  1. Phenanthroline-derived ratiometric chemosensor for ureas. Engel, Y., Dahan, A., Rozenshine-Kemelmakher, E., Gozin, M. J. Org. Chem. (2007) [Pubmed]
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