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Kouprina, N. et al.

Natalay Kouprina, Vladimir N. Noskov, Greg Solomon, John Otstot, William Isaacs, Jianfeng Xu, Johanna Schleutker, Vladimir Larionov,

Mutational analysis of SPANX genes in families with X-linked prostate cancer.

BACKGROUND: Previous genetic linkage studies identified a locus for susceptibility to prostate cancer called HPCX at Xq27. The candidate region contains two clusters of SPANX genes. The first cluster called SPANX-A/D includes SPANX-A1, SPANX-A2, SPANX-B, SPANX-C, and SPANX-D; the second cluster called SPANX-N includes SPANX-N1, SPANX-N2, SPANX-N3, and SPANX-N4. The SPANX genes encode cancer-testis (CT) specific antigens. Previous studies identified SPANX-B and SPANX-D variants produced by gene conversion events, none of which are associated with X-linked prostate cancer. METHODS: In this study we applied transformation-associated recombination cloning (TAR) in yeast to analyze sequence variations in SPANX-A1, SPANX-A2, and SPANX-C genes that are resided within large chromosomal duplications. A SPANX-N1/N4 cluster was analyzed by a routine PCR analysis. RESULTS: None of the sequence variations in the coding regions of these genes is associated with susceptibility to prostate cancer. CONCLUSIONS: Therefore, genetic variation in the SPANX genes is not the actual target variants explaining HPCX. However, it is possible that they play a modifying role in susceptibility to prostate cancer through complex recombinational interaction.[1]

References

Mutational analysis of SPANX genes in families with X-linked prostate cancer. Kouprina, N., Noskov, V.N., Solomon, G., Otstot, J., Isaacs, W., Xu, J., Schleutker, J., Larionov, V. Prostate (2007) [Pubmed]

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