Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Taguchi, A. et al.

Akihiko Taguchi, Zhongmin Wen, Kazunori Myojin, Tomoyuki Yoshihara, Takayuki Nakagomi, Daisuke Nakayama, Hidekazu Tanaka, Toshihiro Soma, David M. Stern, Hiroaki Naritomi, Tomohiro Matsuyama,

Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model.

The administration of CD34-positive cells after stroke has been shown to have a beneficial effect on functional recovery by accelerating angiogenesis and neurogenesis in rodent models. Granulocyte colony-stimulating factor (G-CSF) is known to mobilize CD34-positive cells from bone marrow and has displayed neuroprotective properties after transient ischemic stress. This led us to investigate the effects of G-CSF administration after stroke in mouse. We utilized permanent ligation of the M1 distal portion of the left middle cerebral artery to develop a reproducible focal cerebral ischemia model in CB-17 mice. Animals treated with G-CSF displayed cortical atrophy and impaired behavioral function compared with controls. The negative effect of G-CSF on outcome was associated with G-CSF induction of an exaggerated inflammatory response, based on infiltration of the peri-infarction area with CD11b-positive and F4/80-positive cells. Although clinical trials with G-CSF have been started for the treatment of myocardial and limb ischemia, our results indicate that caution should be exercised in applying these results to cerebral ischemia.[1]

References

Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model. Taguchi, A., Wen, Z., Myojin, K., Yoshihara, T., Nakagomi, T., Nakayama, D., Tanaka, H., Soma, T., Stern, D.M., Naritomi, H., Matsuyama, T. Eur. J. Neurosci. (2007) [Pubmed]

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