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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.

Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. In the 60 monocrotaline-treated rats, 31 widely dispersed tumors of various cell types were recorded. The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinogen, whereas monocrotaline must first be metabolized before its carcinogenic potential is realized.[1]


  1. Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine. Shumaker, R.C., Robertson, K.A., Hsu, I.C., Allen, J.R. J. Natl. Cancer Inst. (1976) [Pubmed]
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