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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction.

The in situ hydrozirconation-transmetalation-aldehyde addition process is a convenient method for the generation of allylic alcohols. Ongoing research has focused on enhancing the enantioselectivity and substrate scope of this process. A chiral beta-amino thiol scaffold was evaluated in the addition reaction. Amino thiols tend to provide the highest ee's, in part due to the higher affinity of sulfur for zinc over zirconium. A class of valine-based thiol ligands was identified to be effective for the formation of enantiomerically enriched allylic alcohols in terms of low ligand loading and high % ee.[1]

References

  1. Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction. Wipf, P., Jayasuriya, N. Chirality (2008) [Pubmed]
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