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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

valine     (2S)-2-amino-3-methyl-butanoic acid

Synonyms: Valinum, Polyvaline, valina, L-valine, L-valin, ...
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Disease relevance of valine


Psychiatry related information on valine

  • Atypical features were seen more frequently in sporadic 129 V/V CJD and fCJD cases [6].

High impact information on valine

  • These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF [7].
  • The risk was elevated even more among women who were homozygous for the Val allele (OR = 14.1; 95% CI = 1.8-113.4) [1].
  • MAIN OUTCOME MEASURES: Genotype effects (in Met allele carriers vs Val homozygotes) on 5 cognitive domain z scores and magnetic resonance imaging gray matter brain volume measures (Talairach atlas-based cerebral lobes and optimized voxel-based morphometry) were examined using general linear models [8].
  • However, in agreement with the predicted beta-strand conformation of a polyvaline segment, helical SP-C unfolds and transforms into beta-sheet aggregates and amyloid fibrils within a few days in aqueous organic solvents [9].
  • METHODS: In a community-based sample of 1,163 subjects aged 59 to 71 years, we characterized the valine (Val) and methionine (Met) allele of the PRNP polymorphism at codon 129 [10].

Chemical compound and disease context of valine


Biological context of valine


Associations of valine with other chemical compounds

  • Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding region [18].
  • This latter problem can be circumvented by replacing the polyvaline stretch of SP-C with a polyleucine stretch containing a few lysines [19].

Gene context of valine


Analytical, diagnostic and therapeutic context of valine

  • In patients with complete response (CR), the 5-year progression-free survival (PFS) was 69% for patients with antibody response and/or V/V genotype, while the PFS was only 40% for patients with neither; the median time to progression (TTP) was 10.47 versus 3.46 years (P = .012) [2].


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  7. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., Weinberger, D.R. Cell (2003) [Pubmed]
  8. Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Ho, B.C., Milev, P., O'Leary, D.S., Librant, A., Andreasen, N.C., Wassink, T.H. Arch. Gen. Psychiatry (2006) [Pubmed]
  9. The N-terminal propeptide of lung surfactant protein C is necessary for biosynthesis and prevents unfolding of a metastable alpha-helix. Li, J., Hosia, W., Hamvas, A., Thyberg, J., Jörnvall, H., Weaver, T.E., Johansson, J. J. Mol. Biol. (2004) [Pubmed]
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  14. CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women. Juo, S.H., Wang, T.N., Lee, J.N., Wu, M.T., Long, C.Y., Tsai, E.M. Hum. Reprod. (2006) [Pubmed]
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  16. A putative polymorphic Val44Ala variation in the synphilin-1 gene is undetectable in Japanese sporadic Parkinson's disease patients. Satoh, J.I., Kuroda, Y. Eur. J. Neurol. (2002) [Pubmed]
  17. Characteristics of the beta myosin heavy chain gene Ala26Val mutation in a Chinese family with hypertrophic cardiomyopathy. Liu, S.X., Hu, S.J., Sun, J., Wang, J., Wang, X.T., Jiang, Y., Cai, J. Eur. J. Intern. Med. (2005) [Pubmed]
  18. Polymorphisms of the prion protein gene in Italian patients with Creutzfeldt-Jakob disease. Salvatore, M., Genuardi, M., Petraroli, R., Masullo, C., D'Alessandro, M., Pocchiari, M. Hum. Genet. (1994) [Pubmed]
  19. Artificial surfactants based on analogues of SP-B and SP-C. Johansson, J., Curstedt, T., Robertson, B. Pediatric pathology & molecular medicine. (2001) [Pubmed]
  20. Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia. Numata, S., Ueno, S., Iga, J., Yamauchi, K., Hongwei, S., Kinouchi, S., Shibuya-Tayoshi, S., Tayoshi, S., Aki, H., Sumitani, S., Itakura, M., Ohmori, T. Journal of neural transmission (Vienna, Austria : 1996) (2007) [Pubmed]
  21. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Romieu, I., Ramirez-Aguilar, M., Sienra-Monge, J.J., Moreno-Mac??as, H., Del Rio-Navarro, B.E., David, G., Marzec, J., Hern??ndez-Avila, M., London, S. Eur. Respir. J. (2006) [Pubmed]
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  23. Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation. Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
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