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Inzucchi, S.E. et al.

Silvio E. Inzucchi, Darren K. McGuire,

New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond.

This is the second of a 2-part series focusing on newer therapies for type 2 diabetes and their cardiovascular implications. In the first segment, we reviewed the thiazolidinediones, highlighting emerging data concerning their cardiovascular effects, both positive and negative. Here, we present a corresponding discussion of the newest antihyperglycemic category, modulators of the incretin system, which include the glucagon-like peptide-1 mimetics and the dipeptidyl peptidase-4 inhibitors. In addition, we briefly survey several novel drug classes in development, provide summary recommendations for glucose-lowering regimens in specific patient types, underscore the importance of nonglucose cardiovascular risk reduction strategies, and comment on present and future considerations for the regulatory review of diabetes drugs.[1]

References

New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond. Inzucchi, S.E., McGuire, D.K. Circulation (2008) [Pubmed]

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