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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.

PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens containing this combination may radically shorten the treatment of multidrug-resistant tuberculosis.[1]

References

  1. Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis. Nuermberger, E., Tyagi, S., Tasneen, R., Williams, K.N., Almeida, D., Rosenthal, I., Grosset, J.H. Antimicrob. Agents Chemother. (2008) [Pubmed]
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