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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor.Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential.Two patients with NPC, who had previously received multi-round therapy, were treated with cidofovir.Cidofovir was topically injected in and around the tumor once every 3 weeks (originally 75 mg/ml sulution, diluted to 15 mg/ml just before injection, 37.5 mg of cidofovir at a time).Tumor growth was suppressed for several months around the injection site in each patient.EBV-encoded RNAs in situ hybridization revealed the reduction of the tumor cell population; however, the EBER expression was still maintained in the NPC tumor cells.Although the anti-tumor mechanism remains unclear, these results suggest that cidofovir is actually an effective and safe agent for the treatment of NPC.[1]
