The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Herpesvirus 4, Human

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Herpesvirus 4, Human


Psychiatry related information on Herpesvirus 4, Human


High impact information on Herpesvirus 4, Human

  • Indeed, in patients with the X-linked lymphoproliferative disease, the inability to control Epstein-Barr virus infections may be consequent to a major dysfunction of 2B4 that exerts inhibitory instead of activating functions [10].
  • The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction [11].
  • BACKGROUND: It is probable but unproven that Epstein-Barr virus (EBV) has a role in nasopharyngeal carcinoma [2].
  • Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin [12].
  • Tumors from six of the patients with post-transplantation lymphoproliferative disease were positive for EBV and expressed LMP1; two samples were EBV-negative [13].

Chemical compound and disease context of Herpesvirus 4, Human


Biological context of Herpesvirus 4, Human

  • Moreover, preliminary results of virus infections of a mouse in which the SAP/SH2D1A gene has been disrupted suggest that EBV infection is not per se critical for the development of XLP phenotypes [1].
  • Immune NOS activity is involved in maintaining EBV latency through down-regulation of the expression of the immediate-early EBV transactivator Zta [16].
  • The malignant cells latently infected with EBV typically express the transcription factor EBNA2 as one of nine latent viral genes [19].
  • Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa [20].
  • The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3 [21].

Anatomical context of Herpesvirus 4, Human


Gene context of Herpesvirus 4, Human


Analytical, diagnostic and therapeutic context of Herpesvirus 4, Human


  1. X-linked lymphoproliferative disease: a progressive immunodeficiency. Morra, M., Howie, D., Grande, M.S., Sayos, J., Wang, N., Wu, C., Engel, P., Terhorst, C. Annu. Rev. Immunol. (2001) [Pubmed]
  2. Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. Chien, Y.C., Chen, J.Y., Liu, M.Y., Yang, H.I., Hsu, M.M., Chen, C.J., Yang, C.S. N. Engl. J. Med. (2001) [Pubmed]
  3. Transfusion-associated hepatitis not due to viral hepatitis type A or B. Feinstone, S.M., Kapikian, A.Z., Purcell, R.H., Alter, H.J., Holland, P.V. N. Engl. J. Med. (1975) [Pubmed]
  4. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Coffey, A.J., Brooksbank, R.A., Brandau, O., Oohashi, T., Howell, G.R., Bye, J.M., Cahn, A.P., Durham, J., Heath, P., Wray, P., Pavitt, R., Wilkinson, J., Leversha, M., Huckle, E., Shaw-Smith, C.J., Dunham, A., Rhodes, S., Schuster, V., Porta, G., Yin, L., Serafini, P., Sylla, B., Zollo, M., Franco, B., Bolino, A., Seri, M., Lanyi, A., Davis, J.R., Webster, D., Harris, A., Lenoir, G., de St Basile, G., Jones, A., Behloradsky, B.H., Achatz, H., Murken, J., Fassler, R., Sumegi, J., Romeo, G., Vaudin, M., Ross, M.T., Meindl, A., Bentley, D.R. Nat. Genet. (1998) [Pubmed]
  5. Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. Kamel, O.W., van de Rijn, M., Weiss, L.M., Del Zoppo, G.J., Hench, P.K., Robbins, B.A., Montgomery, P.G., Warnke, R.A., Dorfman, R.F. N. Engl. J. Med. (1993) [Pubmed]
  6. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment. Chapman, C.J., Spellerberg, M.B., Smith, G.A., Carter, S.J., Hamblin, T.J., Stevenson, F.K. J. Immunol. (1993) [Pubmed]
  7. Volatile nitrosamine levels and genotoxicity of food samples from high-risk areas for nasopharyngeal carcinoma before and after nitrosation. Poirier, S., Bouvier, G., Malaveille, C., Ohshima, H., Shao, Y.M., Hubert, A., Zeng, Y., de Thé, G., Bartsch, H. Int. J. Cancer (1989) [Pubmed]
  8. Epstein-Barr virus induces GM-CSF synthesis by monocytes: effect on EBV-induced IL-1 and IL-1 receptor antagonist production in neutrophils. Roberge, C.J., Larochelle, B., Rola-Pleszczynski, M., Gosselin, J. Virology (1997) [Pubmed]
  9. Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy. Burighel, N., Ghezzi, S., Nozza, S., Del Bianco, P., Lazzarin, A., Tambussi, G., Poli, G., De Rossi, A. Haematologica (2006) [Pubmed]
  10. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M.C., Biassoni, R., Moretta, L. Annu. Rev. Immunol. (2001) [Pubmed]
  11. Interleukin-10. Moore, K.W., O'Garra, A., de Waal Malefyt, R., Vieira, P., Mosmann, T.R. Annu. Rev. Immunol. (1993) [Pubmed]
  12. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Dhar, S.K., Yoshida, K., Machida, Y., Khaira, P., Chaudhuri, B., Wohlschlegel, J.A., Leffak, M., Yates, J., Dutta, A. Cell (2001) [Pubmed]
  13. Epstein-Barr virus and a cellular signaling pathway in lymphomas from immunosuppressed patients. Liebowitz, D. N. Engl. J. Med. (1998) [Pubmed]
  14. Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. Straus, S.E., Dale, J.K., Tobi, M., Lawley, T., Preble, O., Blaese, R.M., Hallahan, C., Henle, W. N. Engl. J. Med. (1988) [Pubmed]
  15. Epstein-Barr virus replication in oropharyngeal epithelial cells. Sixbey, J.W., Nedrud, J.G., Raab-Traub, N., Hanes, R.A., Pagano, J.S. N. Engl. J. Med. (1984) [Pubmed]
  16. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Mannick, J.B., Asano, K., Izumi, K., Kieff, E., Stamler, J.S. Cell (1994) [Pubmed]
  17. Retinoic acid inhibition of Epstein-Barr virus induction. Yamamoto, N., Bister, K., zur Hausen, H. Nature (1979) [Pubmed]
  18. Effect of chloroquine on Epstein-Barr virus expression. Lenoir, G., Geser, A. Nature (1979) [Pubmed]
  19. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Franken, M., Estabrooks, A., Cavacini, L., Sherburne, B., Wang, F., Scadden, D.T. Nat. Med. (1996) [Pubmed]
  20. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Henkel, T., Ling, P.D., Hayward, S.D., Peterson, M.G. Science (1994) [Pubmed]
  21. Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen. Hennessy, K., Heller, M., van Santen, V., Kieff, E. Science (1983) [Pubmed]
  22. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Cheah, M.S., Ley, T.J., Tronick, S.R., Robbins, K.C. Nature (1986) [Pubmed]
  23. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation. Dawson, C.W., Rickinson, A.B., Young, L.S. Nature (1990) [Pubmed]
  24. Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus. Fåhraeus, R., Rymo, L., Rhim, J.S., Klein, G. Nature (1990) [Pubmed]
  25. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Lang, H.L., Jacobsen, H., Ikemizu, S., Andersson, C., Harlos, K., Madsen, L., Hjorth, P., Sondergaard, L., Svejgaard, A., Wucherpfennig, K., Stuart, D.I., Bell, J.I., Jones, E.Y., Fugger, L. Nat. Immunol. (2002) [Pubmed]
  26. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C., Kieff, E. Cell (1995) [Pubmed]
  27. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Hsu, D.H., de Waal Malefyt, R., Fiorentino, D.F., Dang, M.N., Vieira, P., de Vries, J., Spits, H., Mosmann, T.R., Moore, K.W. Science (1990) [Pubmed]
  28. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Moore, K.W., Vieira, P., Fiorentino, D.F., Trounstine, M.L., Khan, T.A., Mosmann, T.R. Science (1990) [Pubmed]
  29. Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein. Morrison, T.E., Mauser, A., Wong, A., Ting, J.P., Kenney, S.C. Immunity (2001) [Pubmed]
  30. The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. Lee, E.S., Locker, J., Nalesnik, M., Reyes, J., Jaffe, R., Alashari, M., Nour, B., Tzakis, A., Dickman, P.S. N. Engl. J. Med. (1995) [Pubmed]
  31. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. Ascherio, A., Munger, K.L., Lennette, E.T., Spiegelman, D., Hernán, M.A., Olek, M.J., Hankinson, S.E., Hunter, D.J. JAMA (2001) [Pubmed]
  32. Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells. Deacon, E.M., Pallesen, G., Niedobitek, G., Crocker, J., Brooks, L., Rickinson, A.B., Young, L.S. J. Exp. Med. (1993) [Pubmed]
  33. Infection of human thymocytes by Epstein-Barr virus. Watry, D., Hedrick, J.A., Siervo, S., Rhodes, G., Lamberti, J.J., Lambris, J.D., Tsoukas, C.D. J. Exp. Med. (1991) [Pubmed]
  34. Infection of human endothelial cells with Epstein-Barr virus. Jones, K., Rivera, C., Sgadari, C., Franklin, J., Max, E.E., Bhatia, K., Tosato, G. J. Exp. Med. (1995) [Pubmed]
WikiGenes - Universities