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MeSH Review

Herpesvirus 4, Human

 
 
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Disease relevance of Herpesvirus 4, Human

 

Psychiatry related information on Herpesvirus 4, Human

 

High impact information on Herpesvirus 4, Human

  • Indeed, in patients with the X-linked lymphoproliferative disease, the inability to control Epstein-Barr virus infections may be consequent to a major dysfunction of 2B4 that exerts inhibitory instead of activating functions [10].
  • The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction [11].
  • BACKGROUND: It is probable but unproven that Epstein-Barr virus (EBV) has a role in nasopharyngeal carcinoma [2].
  • Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin [12].
  • Tumors from six of the patients with post-transplantation lymphoproliferative disease were positive for EBV and expressed LMP1; two samples were EBV-negative [13].
 

Chemical compound and disease context of Herpesvirus 4, Human

 

Biological context of Herpesvirus 4, Human

  • Moreover, preliminary results of virus infections of a mouse in which the SAP/SH2D1A gene has been disrupted suggest that EBV infection is not per se critical for the development of XLP phenotypes [1].
  • Immune NOS activity is involved in maintaining EBV latency through down-regulation of the expression of the immediate-early EBV transactivator Zta [16].
  • The malignant cells latently infected with EBV typically express the transcription factor EBNA2 as one of nine latent viral genes [19].
  • Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa [20].
  • The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3 [21].
 

Anatomical context of Herpesvirus 4, Human

 

Gene context of Herpesvirus 4, Human

 

Analytical, diagnostic and therapeutic context of Herpesvirus 4, Human

References

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  14. Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. Straus, S.E., Dale, J.K., Tobi, M., Lawley, T., Preble, O., Blaese, R.M., Hallahan, C., Henle, W. N. Engl. J. Med. (1988) [Pubmed]
  15. Epstein-Barr virus replication in oropharyngeal epithelial cells. Sixbey, J.W., Nedrud, J.G., Raab-Traub, N., Hanes, R.A., Pagano, J.S. N. Engl. J. Med. (1984) [Pubmed]
  16. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Mannick, J.B., Asano, K., Izumi, K., Kieff, E., Stamler, J.S. Cell (1994) [Pubmed]
  17. Retinoic acid inhibition of Epstein-Barr virus induction. Yamamoto, N., Bister, K., zur Hausen, H. Nature (1979) [Pubmed]
  18. Effect of chloroquine on Epstein-Barr virus expression. Lenoir, G., Geser, A. Nature (1979) [Pubmed]
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  20. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Henkel, T., Ling, P.D., Hayward, S.D., Peterson, M.G. Science (1994) [Pubmed]
  21. Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen. Hennessy, K., Heller, M., van Santen, V., Kieff, E. Science (1983) [Pubmed]
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