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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.

Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.[1]

References

  1. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Papazian, D.M., Timpe, L.C., Jan, Y.N., Jan, L.Y. Nature (1991) [Pubmed]
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