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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Maximum effect of triptans in migraine? A comment.

The efficacy of triptans in the treatment of migraine was recently contested. How high is then the maximum effect of a triptan? After subcutaneous naratriptan 10 mg a 88% pain-free response was observed. This result was obtained despite the fact that more half of the patients had a migraine duration of > 4 h. These results indicate that subcutaneous naratriptan in a high dose can overcome central sensitization that occurs in migraine attacks.[1]


  1. Maximum effect of triptans in migraine? A comment. Tfelt-Hansen, P. Cephalalgia (2008) [Pubmed]
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