The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Colatan     N-methyl-2-[3-(1-methyl-4- piperidyl)-1H...

Synonyms: Naramig, Amerge, naratriptan, naratriptanum, naratriptan;, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C07792


High impact information on C07792


Chemical compound and disease context of C07792


Biological context of C07792


Anatomical context of C07792


Associations of C07792 with other chemical compounds


Gene context of C07792


Analytical, diagnostic and therapeutic context of C07792

  • Headache relief was maintained 8, 12, and 24 hours postdose with no use of rescue medication or a second dose of study medication by significantly (p < 0.001) greater percentages of patients after treatment with naratriptan 2.5 mg or 1 mg compared with naratriptan 0.25 mg or placebo [3].
  • The efficacy and tolerability of naratriptan tablets (2.5 mg, 1 mg, and 0.25 mg) compared with placebo in the acute treatment of migraine were evaluated in a randomized, double-blind, four-period crossover study [3].
  • We conducted this series of experiments to further elucidate the site of action of naratriptan using a well-established animal model of trigeminovascular stimulation [27].
  • Cardiac haemodynamics and coronary artery diameter were measured at baseline and after subcutaneous injections of placebo and naratriptan (1.5 mg, s.c.) in 10 patients undergoing diagnostic cardiac catheterisation [28].
  • Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials [29].


  1. Naratriptan is effective and well tolerated in the acute treatment of migraine. Tfelt-Hansen, P., Goadsby, P.J. Neurology (1999) [Pubmed]
  2. Effect of naratriptan on myocardial blood flow and coronary vasodilator reserve in migraineurs. Gnecchi-Ruscone, T., Bernard, X., Pierre, P., Anderson, D., Legg, N., Enahoro, H., Winter, P.D., Crisp, A., Melin, J.A., Camici, P.G. Neurology (2000) [Pubmed]
  3. Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group. Mathew, N.T., Asgharnejad, M., Peykamian, M., Laurenza, A. Neurology (1997) [Pubmed]
  4. Triptans reduce the inflammatory response in bacterial meningitis. Hoffmann, O., Keilwerth, N., Bille, M.B., Reuter, U., Angstwurm, K., Schumann, R.R., Dirnagl, U., Weber, J.R. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  5. Naratriptan prophylactic treatment in cluster headache. Eekers, P.J., Koehler, P.J. Cephalalgia : an international journal of headache. (2001) [Pubmed]
  6. Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception. Bartsch, T., Knight, Y.E., Goadsby, P.J. Ann. Neurol. (2004) [Pubmed]
  7. Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review. Jhee, S.S., Shiovitz, T., Crawford, A.W., Cutler, N.R. Clinical pharmacokinetics. (2001) [Pubmed]
  8. Modulation of neuronal activity in the nucleus raphé magnus by the 5-HT(1)-receptor agonist naratriptan in rat. Ellrich, J., Messlinger, K., Chiang, C.Y., Hu, J.W. Pain (2001) [Pubmed]
  9. The sumatriptan/naratriptan aggregated patient (SNAP) database: aggregation, validation and application. Barrows, C., Saunders, W., Austin, R., Putnam, G., Mansbach, H. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  10. Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. Garcia-Ramos, G., MacGregor, E.A., Hilliard, B., Bordini, C.A., Leston, J., Hettiarachchi, J. Cephalalgia : an international journal of headache. (2003) [Pubmed]
  11. Naratriptan in the preventive treatment of cluster headache. Mulder, L.J., Spierings, E.L. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  12. The combination of naratriptan and prochlorperazine in migraine treatment. Tietjen, G.E., Athanas, K., Utley, C., Herial, N.A., Khuder, S.A. Headache. (2005) [Pubmed]
  13. Effects of naratriptan versus naproxen on daily functioning in the acute treatment of migraine: a randomized, double-blind, double-dummy, crossover study. Stronks, D.L., Tulen, J.H., Bussmann, H.B., Mulder, L.J., Passchier, J. Headache. (2003) [Pubmed]
  14. Naratriptan: biological profile in animal models relevant to migraine. Connor, H.E., Feniuk, W., Beattie, D.T., North, P.C., Oxford, A.W., Saynor, D.A., Humphrey, P.P. Cephalalgia : an international journal of headache. (1997) [Pubmed]
  15. Uncertainty analysis in pharmacokinetics and pharmacodynamics: application to naratriptan. Gueorguieva, I., Nestorov, I.A., Aarons, L., Rowland, M. Pharm. Res. (2005) [Pubmed]
  16. Efficacy of oral naratriptan in the treatment of menstrually related migraine. Massiou, H., Jamin, C., Hinzelin, G., Bidaut-Mazel, C. Eur. J. Neurol. (2005) [Pubmed]
  17. Preclinical neuropharmacology of naratriptan. Lambert, G.A. CNS drug reviews. (2005) [Pubmed]
  18. Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding. Dupuis, D.S., Palmier, C., Colpaert, F.C., Pauwels, P.J. J. Neurochem. (1998) [Pubmed]
  19. Differential effects of the 5HT1B/1D receptor agonist naratriptan on trigeminal versus spinal nociceptive responses. Cumberbatch, M.J., Hill, R.G., Hargreaves, R.J. Cephalalgia : an international journal of headache. (1998) [Pubmed]
  20. Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery. Akin, D., Onaran, H.O., Gurdal, H. Br. J. Pharmacol. (2002) [Pubmed]
  21. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Hoskin, K.L., Lambert, G.A., Donaldson, C., Zagami, A.S. Brain Res. (2004) [Pubmed]
  22. Recombinant saphenous vein 5-HT1B receptors of the rabbit: comparative pharmacology with human 5-HT1B receptors. Wurch, T., Palmier, C., Colpaert, F.C., Pauwels, P.J. Br. J. Pharmacol. (1997) [Pubmed]
  23. Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. Jähnichen, S., Radtke, O.A., Pertz, H.H. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  24. Eletriptan Pfizer. Strijbos, P.J., Parsons, A.A., Fugelli, A. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]
  25. Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgammaS-binding responses in the human and monkey brain. Dupuis, D.S., Pauwels, P.J., Radu, D., Hall, H. Eur. J. Neurosci. (1999) [Pubmed]
  26. Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935. Pauwels, P.J., Colpaert, F.C. Eur. J. Pharmacol. (1996) [Pubmed]
  27. Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy. Boers, P.M., Donaldson, C., Zagami, A.S., Lambert, G.A. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  28. Effects of subcutaneous naratriptan on systemic and pulmonary haemodynamics and coronary artery diameter in humans. Hood, S., Birnie, D., Swan, L., Murray, L.S., Whitehouse, H., Winter, P., Hillis, W.S. J. Cardiovasc. Pharmacol. (1999) [Pubmed]
  29. Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials. Ashcroft, D.M., Millson, D. Pharmacoepidemiology and drug safety. (2004) [Pubmed]
WikiGenes - Universities