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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae.

In this study, several cytokine responses were investigated during Mycoplasma hyopneumoniae (Mhp) infection using a gnotobiotic infection model. We found that several inflammatory cytokines (IL-1beta, IL-8, IL-18, and TNF-alpha) and an anti-inflammatory cytokine IL-10 were induced from peripheral blood mononuclear cells (PBMC) of germ-free (GF) piglets stimulated with heat killed Mhp whole antigens, but no IFN-gamma and IL-4 were induced by Mhp. After the intranasal infection of Mhp, IL-1beta, IL-8, IL-18, and IFN-gamma were also detected in the broncho-alveolar lavage fluids (BALF). The antigen-specific IFN-gamma and IL-10 responses after infection of Mhp were gradually suppressed during Mhp infection as well as non-specific immune response to concanavalin A (ConA) and lipopolysacchalide (LPS) at early stage of infection. These results suggested that Mhp infection modulates the immune response of pigs by inducing several cytokines, and causes immuno-suppression of pigs in a gnotobiotic condition.[1]


  1. Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae. Muneta, Y., Minagawa, Y., Shimoji, Y., Ogawa, Y., Hikono, H., Mori, Y. J. Vet. Med. Sci. (2008) [Pubmed]
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