Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio.
The effect of DN-1417, a thyrotropin-releasing hormone (TRH) analogue, on photosensitivity and cortically kindled seizures was examined in seven Senegalese baboons (Papio papio). Intravenous (i.v.) administration of 2 mg/kg had no effect on either photosensitivity or cortically kindled seizures. When this agent was administered intracisternally, both the photomyoclonic response and cortically kindled seizures were suppressed for 4-5 days. A study of the transcallosal response also showed a long-lasting attenuation of the early positive wave (P1) amplitude (peak latency, 5-10 ms) elicited by a single stimulus after cisternal injection of DN-1417. These findings are consistent with the assumption that endogenous TRH is involved in suppression of epileptic seizures.[1]References
- Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio. Sakai, S., Baba, H., Sato, M., Wada, J.A. Epilepsia (1991) [Pubmed]
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