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Chemical Compound Review

SureCN3095494     2-hydroxypropane-1,2,3- tricarboxylic acid;...

Synonyms: DN-1417, AC1L4GZT, AC1Q74U0, 96861-08-4, 77026-80-3 (Parent)
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Disease relevance of DN 1417


Psychiatry related information on DN 1417


High impact information on DN 1417


Chemical compound and disease context of DN 1417


Biological context of DN 1417


Anatomical context of DN 1417


Associations of DN 1417 with other chemical compounds


Gene context of DN 1417

  • The results suggest that TRH, MK-771 and DN-1417, in behaviorally active doses, exert a marked endocrine effect on prolactin secretion in estrogen-primed rats, but not in ovariectomized rats or normal male rats [22].
  • Effect of TRH analog (DN-1417) on tyrosine hydroxylase activity in mesocortical, mesolimbic and nigrostriatal dopaminergic neurons of rat brain [23].
  • In the prefrontal cortex medial field, nucleus accumbens and olfactory tubercles, TH activity assayed under the suboptimal condition was not modified by DN-1417 treatment [23].
  • These results suggest that GRP, NT and DN 1417 act at the hypothalamic catecholamine nerve terminals and stimulate the release of DA and NE in the rat [19].
  • The present study showed that DN-1417 had a dose-dependent anticonvulsant activity on El mouse seizure [24].

Analytical, diagnostic and therapeutic context of DN 1417


  1. Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417. Hawley, R.J., Kratz, R., Goodman, R.R., McCutchen, C.B., Sirdofsky, M., Hanson, P.A. Neurology (1987) [Pubmed]
  2. Effect of DN-1417, a thyrotropin releasing hormone analog, on dopaminergic neurons in rat brain. Nakahara, T., Matsumoto, T., Hirano, M., Uchimura, H., Yokoo, H., Nakamura, K., Ishibashi, K., Hirano, H. Peptides (1985) [Pubmed]
  3. Involvement of thyrotropin-releasing hormone (TRH) neural system of the brain in pentylenetetrazol-induced seizures. Ogawa, N., Hirose, Y., Mori, A., Kajita, S., Sato, M. Regul. Pept. (1985) [Pubmed]
  4. Thyrotropin-releasing hormone (TRH) blocks glucagon-induced hyperglycemia in mice: dissociation of the antihyperglycemic and pituitary actions of TRH. Amir, S. Brain Res. (1988) [Pubmed]
  5. A pilot study on the anticonvulsive effects of a thyrotropin-releasing hormone analog in intractable epilepsy. Matsuishi, T., Yano, E., Inanaga, K., Terasawa, K., Ishihara, O., Shiotsuki, Y., Katafuchi, Y., Aoki, N., Yamashita, F. Brain Dev. (1983) [Pubmed]
  6. A TRH analog (DN-1417): motor stimulation with rearing related to catecholaminergic mechanisms in rats. Miyamoto, M., Narumi, S., Nagai, Y., Saji, Y., Nagawa, Y. Neuropharmacology (1984) [Pubmed]
  7. A treatment trial with an analog of thyrotropin-releasing hormone (DN-1417) and des-tyrosine-gamma-endorphin in schizophrenia. Mizuki, Y., Ushijima, I., Yamada, M., Tanaka, M., Inanaga, K. International clinical psychopharmacology. (1986) [Pubmed]
  8. Lack of usefulness of DN-1417 for characterization of a CNS receptor for thyrotropin-releasing hormone. Hawkins, E.F., Wade, R., Engel, W.K. J. Neurochem. (1987) [Pubmed]
  9. Effect of DN-1417 on photosensitivity and cortically kindled seizure in Senegalese baboons, Papio papio. Sakai, S., Baba, H., Sato, M., Wada, J.A. Epilepsia (1991) [Pubmed]
  10. Changes in brain thyrotropin-releasing hormone (TRH) of seizure-prone El mice. Yamashita, K., Mori, A., Otsuki, S. Exp. Neurol. (1990) [Pubmed]
  11. Clinical study of oral administration of DN-1417, a TRH analog, in patients with intractable epilepsy. Inanaga, K., Kumashiro, H., Fukuyama, Y., Ohtahara, S., Shirouzu, M. Epilepsia (1989) [Pubmed]
  12. Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice. Bansinath, M., Bhargava, H.N. Neuropharmacology (1988) [Pubmed]
  13. Seizures and thyrotropin-releasing hormone (TRH) neural system in the rat brain. Ogawa, N., Kajita, S., Sato, M., Mori, A. Folia psychiatrica et neurologica japonica. (1985) [Pubmed]
  14. Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord. Ono, H., Fukuda, H. Neuropharmacology (1982) [Pubmed]
  15. Effects of a new thyrotropin-releasing hormone analogue (DN-1417) on evoked responses and long-term potentiation in the dentate gyrus of rat. Morimoto, K., Goddard, G.V., Sirett, N.E. Neurosci. Lett. (1986) [Pubmed]
  16. Effect of TRH and DN-1417 on the vestibulo-ocular reflex in squirrel monkeys. Ishii, M., Igarashi, M., Honda, Y. Acta oto-laryngologica. Supplementum. (1988) [Pubmed]
  17. Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance. Rinehart, R.K., Barbaz, B., Iyengar, S., Ambrose, F., Steel, D.J., Neale, R.F., Petrack, B., Bittiger, H., Wood, P.L., Williams, M. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  18. Inhibition by DN-1417 (a TRH derivative) of [3H]GABA binding in the rat brain. Tatsuoka, Y., Kato, Y., Imura, H. Neurosci. Lett. (1983) [Pubmed]
  19. Stimulation by gastrin-releasing peptide, neurotensin and DN1417, a novel TRH analog, of dopamine and norepinephrine release from perifused rat hypothalamic fragments in vitro. Kabayama, Y., Kato, Y., Shimatsu, A., Yanaihara, N., Imura, H. Brain Res. (1986) [Pubmed]
  20. A treatment trial with an analog of thyrotropin-releasing hormone (DN-1417) in schizophrenia. Mizuki, Y., Nishikori, S., Kajimura, N., Imaizumi, J., Yamada, M., Inanaga, K. Biol. Psychiatry (1985) [Pubmed]
  21. Intracerebroventricular injection of a TRH analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-prolinamide, induces gastric lesions and gastric acid stimulation in rats. Maeda-Hagiwara, M., Watanabe, H. Naunyn Schmiedebergs Arch. Pharmacol. (1985) [Pubmed]
  22. Effects of thyrotropin-releasing hormone analogues on body shaking and prolactin levels in estrogen-primed and nonprimed rats. Yamada, K., Kumagai, M., Nagashima, M., Matsuo, N., Furukawa, T. Archives internationales de pharmacodynamie et de thérapie. (1989) [Pubmed]
  23. Effect of TRH analog (DN-1417) on tyrosine hydroxylase activity in mesocortical, mesolimbic and nigrostriatal dopaminergic neurons of rat brain. Yokoo, H., Nakahara, T., Matsumoto, T., Inanaga, K., Uchimura, H. Peptides (1987) [Pubmed]
  24. Changes in brain thyrotropin-releasing hormone (TRH) of El mice. Yamashita, K., Nakashima, M., Kajita, S., Hiramatsu, M., Ogawa, N., Mori, A., Sato, M. Jpn. J. Psychiatry Neurol. (1987) [Pubmed]
  25. Radioimmunoassay for an analog of thyrotrophin-releasing hormone, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide (DN-1417). Shiota, K., Miyake, A., Tsunoda, C., Oka, Y., Nagawa, Y., Nakayama, R. J. Immunol. Methods (1982) [Pubmed]
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