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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila.

Sex-specific alternative processing of doublesex (dsx) precursor messenger RNA (pre-mRNA) regulates somatic sexual differentiation in Drosophila melanogaster. Cotransfection analyses in which the dsx gene and the female-specific transformer (tra) and transformer-2 (tra-2) complementary DNAs were expressed in Drosophila Kc cells revealed that female-specific splicing of the dsx transcript was positively regulated by the products of the tra and tra-2 genes. Furthermore, analyses of mutant constructs of dsx showed that a portion of the female-specific exon sequence was required for regulation of dsx pre-messenger RNA splicing.[1]

References

  1. Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Hoshijima, K., Inoue, K., Higuchi, I., Sakamoto, H., Shimura, Y. Science (1991) [Pubmed]
 
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