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Fornaro, M. et al.

Michele Fornaro, Filippo Gabrielli, Chiara Mattei, Valentina Vinciguerra, Pantaleo Fornaro,

Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report.

BACKGROUND: Obsessive-compulsive disorder is associated with a relevant impairment in social and interpersonal functioning and severe disability. This seems to be particularly true for the poor insight subtype, characterised by a lack of consciousness of illness and, consequently, compliance with treatment. Poor responsiveness to serotonergic drugs in poor insight obsessive-compulsive patients may also require an augmentation therapy with atypical antipsychotics. METHODS: We reviewed a case in which a patient with a long history of poor insight obsessive-compulsive disorder was treated with a high dosage of serotonin reuptake inhibitors. RESULTS: The treatment resulted in a poor outcome. This patient was therefore augmentated with aripiprazole. CONCLUSION: Doctors should consider aripiprazole as a possible augmentation strategy for serotonergic poor responder obsessive-compulsive patients, but further research on these subjects is needed.[1]

References

Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report. Fornaro, M., Gabrielli, F., Mattei, C., Vinciguerra, V., Fornaro, P. Ann. Gen. Psychiatry (2008) [Pubmed]

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