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Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.

The antigenotoxic effect of apigenin was studied against the genotoxic damage induced by mitomycin C on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Apigenin was studied at three different doses i.e. 10, 20 and 40 mg/kg b.w. and was found to be non-genotoxic at all the above three doses. Mitomycin C at 2 mg/kg b.w. was given along with the 10, 20 and 40 mg/kg bw of apigenin. A significant decrease in SCEs and CAs was observed, suggesting a protective role of apigenin against the genotoxicity of mitomycin C on mice bone marrow cells.[1]

References

  1. Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells. Siddique, Y.H., Afzal, M. Food Chem. Toxicol. (2009) [Pubmed]
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