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MeSH Review

Chromosome Aberrations

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Disease relevance of Chromosome Aberrations


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Chemical compound and disease context of Chromosome Aberrations


Biological context of Chromosome Aberrations


Anatomical context of Chromosome Aberrations


Gene context of Chromosome Aberrations


Analytical, diagnostic and therapeutic context of Chromosome Aberrations


  1. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Romanov, S.R., Kozakiewicz, B.K., Holst, C.R., Stampfer, M.R., Haupt, L.M., Tlsty, T.D. Nature (2001) [Pubmed]
  2. Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. Marth, J.D., Disteche, C., Pravtcheva, D., Ruddle, F., Krebs, E.G., Perlmutter, R.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Engelkamp, D., Schäfer, B.W., Mattei, M.G., Erne, P., Heizmann, C.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Relationship between an activated N-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome. Hirai, H., Okada, M., Mizoguchi, H., Mano, H., Kobayashi, Y., Nishida, J., Takaku, F. Blood (1988) [Pubmed]
  5. Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10). Wang, L., Ogawa, S., Hangaishi, A., Qiao, Y., Hosoya, N., Nanya, Y., Ohyashiki, K., Mizoguchi, H., Hirai, H. Blood (2003) [Pubmed]
  6. Critical periods of the mitotic cycle: influence of aminopterin and thymidine on production of chromosomal aberrations by radiation in Crepis capillaris. Luchnik, N.V., Fesenko, E.V., Ovchinnikova, V.G. Mutat. Res. (1976) [Pubmed]
  7. Electroencephalographic and epileptic patterns in X chromosome anomalies. Grosso, S., Farnetani, M.A., Di Bartolo, R.M., Berardi, R., Pucci, L., Mostardini, R., Anichini, C., Bartalini, G., Galimberti, D., Morgese, G., Balestri, P. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2004) [Pubmed]
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  9. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Marmorstein, L.Y., Kinev, A.V., Chan, G.K., Bochar, D.A., Beniya, H., Epstein, J.A., Yen, T.J., Shiekhattar, R. Cell (2001) [Pubmed]
  10. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., Greider, C.W. Cell (1997) [Pubmed]
  11. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M. Nat. Genet. (1996) [Pubmed]
  12. Cloning a balanced translocation associated with DiGeorge syndrome and identification of a disrupted candidate gene. Budarf, M.L., Collins, J., Gong, W., Roe, B., Wang, Z., Bailey, L.C., Sellinger, B., Michaud, D., Driscoll, D.A., Emanuel, B.S. Nat. Genet. (1995) [Pubmed]
  13. Chromosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles. Wramsby, H., Fredga, K., Liedholm, P. N. Engl. J. Med. (1987) [Pubmed]
  14. Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. Hengstler, J.G., Bogdanffy, M.S., Bolt, H.M., Oesch, F. Annu. Rev. Pharmacol. Toxicol. (2003) [Pubmed]
  15. Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells. Meyers, M.B., Spengler, B.A., Chang, T.D., Melera, P.W., Biedler, J.L. J. Cell Biol. (1985) [Pubmed]
  16. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. DiPaolo, J.A., Amsbaugh, S.C., Popescu, N.C. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  17. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Fukuchi, K., Martin, G.M., Monnat, R.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  18. Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice. Tice, R.R., Costa, D.L., Drew, R.T. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  19. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Hannon, G.J., Beach, D. Nature (1994) [Pubmed]
  20. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Nijman, S.M., Huang, T.T., Dirac, A.M., Brummelkamp, T.R., Kerkhoven, R.M., D'Andrea, A.D., Bernards, R. Mol. Cell (2005) [Pubmed]
  21. Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue. Verkarre, V., Romana, S.P., Cellier, C., Asnafi, V., Mention, J.J., Barbe, U., Nusbaum, S., Hermine, O., Macintyre, E., Brousse, N., Cerf-Bensussan, N., Radford-Weiss, I. Gastroenterology (2003) [Pubmed]
  22. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A., Takeda, S. EMBO J. (1998) [Pubmed]
  23. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Hagen, T.M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C.M., Ames, B.N., Chisari, F.V. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse. Marchetti, F., Bishop, J.B., Lowe, X., Generoso, W.M., Hozier, J., Wyrobek, A.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  25. Duplication of part of the long arm of chromosome 1 in marrow cells of a treated case of myelomatosis. Spriggs, A.I., Holt, J.M., Bedford, J. Blood (1976) [Pubmed]
  26. Decrease of the major high molecular weight surface glycoprotein of human granulocytes in monosomy-7 associated with defective chemotaxis. Gahmberg, C.G., Andersson, L.C., Ruutu, P., Timonen, T.T., Hänninen, A., Vuopio, P., de la Chapelle, A. Blood (1979) [Pubmed]
  27. N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome. Paquette, R.L., Landaw, E.M., Pierre, R.V., Kahan, J., Lübbert, M., Lazcano, O., Isaac, G., McCormick, F., Koeffler, H.P. Blood (1993) [Pubmed]
  28. Proliferative kinetics and chromosome damage in trisomy 21 lymphocyte cultures exposed to gamma-rays and bleomycin. Morimoto, K., Kaneko, T., Iijima, K., Koizumi, A. Cancer Res. (1984) [Pubmed]
  29. Genomic instability and endoreduplication triggered by RAD17 deletion. Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S.J., Li, L. Genes Dev. (2003) [Pubmed]
  30. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. Larson, R.C., Lavenir, I., Larson, T.A., Baer, R., Warren, A.J., Wadman, I., Nottage, K., Rabbitts, T.H. EMBO J. (1996) [Pubmed]
  31. Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal. Kwok, C., Weller, P.A., Guioli, S., Foster, J.W., Mansour, S., Zuffardi, O., Punnett, H.H., Dominguez-Steglich, M.A., Brook, J.D., Young, I.D. Am. J. Hum. Genet. (1995) [Pubmed]
  32. Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. Migliazza, A., Lombardi, L., Rocchi, M., Trecca, D., Chang, C.C., Antonacci, R., Fracchiolla, N.S., Ciana, P., Maiolo, A.T., Neri, A. Blood (1994) [Pubmed]
  33. RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Petiniot, L.K., Weaver, Z., Vacchio, M., Shen, R., Wangsa, D., Barlow, C., Eckhaus, M., Steinberg, S.M., Wynshaw-Boris, A., Ried, T., Hodes, R.J. Mol. Cell. Biol. (2002) [Pubmed]
  34. Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. Raynaud, S.D., Baens, M., Grosgeorge, J., Rodgers, K., Reid, C.D., Dainton, M., Dyer, M., Fuzibet, J.G., Gratecos, N., Taillan, B., Ayraud, N., Marynen, P. Blood (1996) [Pubmed]
  35. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. Nakatani, K., Thompson, D.A., Barthel, A., Sakaue, H., Liu, W., Weigel, R.J., Roth, R.A. J. Biol. Chem. (1999) [Pubmed]
  36. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Rozovskaia, T., Feinstein, E., Mor, O., Foa, R., Blechman, J., Nakamura, T., Croce, C.M., Cimino, G., Canaani, E. Oncogene (2001) [Pubmed]
  37. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Akervall, J., Guo, X., Qian, C.N., Schoumans, J., Leeser, B., Kort, E., Cole, A., Resau, J., Bradford, C., Carey, T., Wennerberg, J., Anderson, H., Tennvall, J., Teh, B.T. Clin. Cancer Res. (2004) [Pubmed]
  38. MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia. Fu, J.F., Hsu, H.C., Shih, L.Y. Genes Chromosomes Cancer (2005) [Pubmed]
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