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Damato, B. et al.

Bertil Damato, Justyna Dopierala, Annelies Klaasen, Marcory van Dijk, Julie Sibbring, Sarah E. Coupland,

Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death.

PURPOSE: To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic death. METHODS: Uveal melanoma specimens of 73 patients treated between 1998 and 2000 were included. DNA samples were analyzed with MLPA evaluating 31 loci on chromosomes 1, 3, 6 and 8, and the results were correlated with metastatic death. RESULTS: The patients (27 women; 46 men) had a median age of 60.6 years and a median follow-up of 6.2 years. Metastatic death occurred in 28 patients, correlating most strongly with chromosome 3 losses and gains on 8q (Cox univariate analysis, P < 0.001). Chromosome 6, region p25, gains correlated with good survival (Cox univariate analysis, P = 0.003). Prediction of metastatic death was improved by considering equivocal chromosome 3 losses as abnormal and by taking account of multiple risk factors, such as 8q gains, tumor diameter, and histologic features indicative of high-grade malignancy. CONCLUSIONS: MLPA analysis of uveal melanoma predicts metastatic death if statistically insignificant losses of chromosome 3 are considered together with gains in 8q as well as clinical stage and histologic grade of malignancy.[1]

References

Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death. Damato, B., Dopierala, J., Klaasen, A., van Dijk, M., Sibbring, J., Coupland, S.E. Invest. Ophthalmol. Vis. Sci. (2009) [Pubmed]

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