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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Platinum-catalyzed dehydroalkoxylation-cyclization cascade via N-O bond cleavage.

ortho-Alkynylphenylureas and -acetamides 1, with an alkoxy and aryl group on the nitrogen atom, were subjected to platinum-catalyzed cyclization reactions to afford the corresponding tetracyclic compounds 2, via N-O bond cleavage, in good to excellent yields. For example, N-methoxy-N'-methyl-N'-(2-(pent-1-ynyl)phenyl)-N-phenylurea (1a) was reacted for 12 h in the presence of PtI(4) (10 mol%) in 1,4-dioxane at 100 degrees C to afford 5-methyl-12-propylindolo[1,2-c]quinazolin-6(5H)-one (2a) in 93% yield, via an iminium-bound platinum carbenoid intermediate, followed by an aromatic C-H insertion.[1]


  1. Platinum-catalyzed dehydroalkoxylation-cyclization cascade via N-O bond cleavage. Nakamura, I., Sato, Y., Terada, M. J. Am. Chem. Soc. (2009) [Pubmed]
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