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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Severe monochlorobenzene-induced liver cell necrosis.

Benzene derivatives can induce severe liver cell necrosis in animals. A case of a 40-year-old man whose daily consumption of alcohol was 200 g and who had a severe monochlorobenzene-induced liver necrosis is described. Liver biopsy specimen showed centrilobular and mediolobular necrosis, similar to that in mice after experimental bromobenzene administration. Monochlorobenzene serum concentration, assayed from day 3 to day 15 after poisoning, decreased monoexponentially with a half-life of 40.3 hours. Prostaglandin E1 was administered from day 3 to day 8. The patient ultimately recovered. The mechanism of monochlorobenzene-induced liver injury and the possible aggravating role of chronic alcohol consumption are discussed.[1]


  1. Severe monochlorobenzene-induced liver cell necrosis. Babany, G., Bernuau, J., Cailleux, A., Cadranel, J.F., Degott, C., Erlinger, S., Benhamou, J.P. Gastroenterology (1991) [Pubmed]
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