The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

BROMOBENZOL     bromobenzene

Synonyms: BROMOBENZENE, PhBr, BROMO-BENZENE, p-bromobenzene, SureCN1542, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of bromobenzene


High impact information on bromobenzene


Chemical compound and disease context of bromobenzene


Biological context of bromobenzene

  • Histochemical detection of lipid peroxidation in the liver of bromobenzene-poisoned mice [15].
  • Kinetic studies using reaction calorimetry were carried out under synthetically relevant conditions to study the mechanism of the amination of bromobenzene with primary and secondary amines using Pd(2)(dba)(3)/BINAP mixtures as well as preformed (dba)Pd(BINAP), (p-tolyl)(Br)Pd(BINAP), and Pd(BINAP)(2) complexes [16].
  • Pharmacokinetics of DOX after BRB pretreatment was mildly changed from control [17].
  • With the fluoro-, chloro-, and bromobenzene substrates, the values for the migration and retention of deuterium during hydroxylation (NIH shift) were nearly identical when the deuterium was either at the site of hydroxylation or at an adjacent site, indicating a possible common intermediate [18].
  • Metabolic activation and detoxification of bromobenzene leading to cytotoxicity [19].

Anatomical context of bromobenzene


Associations of bromobenzene with other chemical compounds


Gene context of bromobenzene


Analytical, diagnostic and therapeutic context of bromobenzene


  1. Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice. Casini, A.F., Ferrali, M., Pompella, A., Maellaro, E., Comporti, M. Am. J. Pathol. (1986) [Pubmed]
  2. Phase I and phase II metabolism of lithocholic acid in hepatic acinar zone 3 necrosis. Evaluation in rats by combined radiochromatography and gas-liquid chromatography-mass spectrometry. Dionne, S., Tuchweber, B., Plaa, G.L., Yousef, I.M. Biochem. Pharmacol. (1994) [Pubmed]
  3. Influence of hypoxic and hypercapnic acidosis on brain water content after forebrain ischemia in the rat. Morimoto, Y., Yamamura, T., Kemmotsu, O. Crit. Care Med. (1993) [Pubmed]
  4. Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. Smith, A.C., Berman, M.L., James, R.C., Harbison, R.D. Biochem. Pharmacol. (1983) [Pubmed]
  5. Antagonism of bromobenzene-induced hepatotoxicity by the alpha-adrenoreceptor blocking agents phentolamine and idazoxan: role of hypothermia. Kerger, B.D., Roberts, S.M., Harbison, R.D., James, R.C. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  6. Bromobenzene accelerates hepatocyte streaming in rats. Arber, N., Zajicek, G., Shamir, R., Kenet, G., Raanani, P., Nordenberg, J., Sidi, Y. Gastroenterology (1992) [Pubmed]
  7. Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice. Tinel, M., Berson, A., Vadrot, N., Descatoire, V., Grodet, A., Feldmann, G., Thénot, J.P., Pessayre, D. Hepatology (2004) [Pubmed]
  8. Methyl-donor deficiency due to chemically induced glutathione depletion. Lertratanangkoon, K., Orkiszewski, R.S., Scimeca, J.M. Cancer Res. (1996) [Pubmed]
  9. Evidence suggesting that the two forms of heme oxygenase are products of different genes. Cruse, I., Maines, M.D. J. Biol. Chem. (1988) [Pubmed]
  10. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Maellaro, E., Casini, A.F., Del Bello, B., Comporti, M. Biochem. Pharmacol. (1990) [Pubmed]
  11. Cellular toxicity of bromobenzene and bromobenzene metabolites to rabbit proximal tubules: the role and mechanism of 2-bromohydroquinone. Schnellmann, R.G., Mandel, L.J. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  12. Protective effect of 16,16-dimethyl prostaglandin E2 on the hepatotoxicity of bromobenzene in mice. Funck-Brentano, C., Tinel, M., Degott, C., Letteron, P., Babany, G., Pessayre, D. Biochem. Pharmacol. (1984) [Pubmed]
  13. Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. Hayes, M.A., Pickering, D.B. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  14. Metabolic activation and hepatotoxicity. Toxicity of bromobenzene in hepatocytes isolated from phenobarbital-and diethylmaleate-treated rats. Thor, J., Moldéus, P., Hermanson, R., Högberg, J., Reed, D.J., Orrenius, S. Arch. Biochem. Biophys. (1978) [Pubmed]
  15. Histochemical detection of lipid peroxidation in the liver of bromobenzene-poisoned mice. Pompella, A., Maellaro, E., Casini, A.F., Comporti, M. Am. J. Pathol. (1987) [Pubmed]
  16. Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions. Singh, U.K., Strieter, E.R., Blackmond, D.G., Buchwald, S.L. J. Am. Chem. Soc. (2002) [Pubmed]
  17. Effect of sublethal liver injury on doxorubicin metabolism. August, D.A., Halter, S., Brenner, D.E. Clin. Cancer Res. (1995) [Pubmed]
  18. NIH shift in the hydroxylation of aromatic compounds by the ammonia-oxidizing bacterium Nitrosomonas europaea. Evidence against an arene oxide intermediate. Vannelli, T., Hooper, A.B. Biochemistry (1995) [Pubmed]
  19. Metabolic activation and detoxification of bromobenzene leading to cytotoxicity. Lau, S.S., Abrams, G.D., Zannoni, V.G. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  20. Induction of heme oxygenase in rat liver. Increase of the specific mRNA by treatment with various chemicals and immunological identity of the enzymes in various tissues as well as the induced enzymes. Ishizawa, S., Yoshida, T., Kikuchi, G. J. Biol. Chem. (1983) [Pubmed]
  21. Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol. Koen, Y.M., Williams, T.D., Hanzlik, R.P. Chem. Res. Toxicol. (2000) [Pubmed]
  22. Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene. Koen, Y.M., Hanzlik, R.P. Chem. Res. Toxicol. (2002) [Pubmed]
  23. Early mitochondrial disfunction in bromobenzene treated mice: a possible factor of liver injury. Maellaro, E., Del Bello, B., Casini, A.F., Comporti, M., Ceccarelli, D., Muscatello, U., Masini, A. Biochem. Pharmacol. (1990) [Pubmed]
  24. Acinar distribution of liver cell regeneration after selective zonal injury in the rat. Nostrant, T.T., Miller, D.L., Appelman, H.D., Gumucio, J.J. Gastroenterology (1978) [Pubmed]
  25. Bromobenzene metabolism in isolated rat hepatocytes. 18O2 incorporation studies. Dankovic, D., Billings, R.E., Seifert, W., Stillwell, W.G. Mol. Pharmacol. (1985) [Pubmed]
  26. Effects of vitamins E, C and catalase on bromobenzene- and hydrogen peroxide-induced intracellular oxidation and DNA single-strand breakage in Hep G2 cells. Wu, J., Karlsson, K., Danielsson, A. J. Hepatol. (1997) [Pubmed]
  27. Beta-N-acetylhexosaminidase in the urine, kidney and serum of bromobenzene-intoxicated mice. Tassi, C., Beccari, T., Casini, A., Orlacchio, A. Clin. Chim. Acta (1992) [Pubmed]
  28. Cytochrome P-450 system dependent depression of delta-aminolevulinic acid dehydratase activity by bromobenzene in rats. Koizumi, A., Fujita, H., Sadamoto, T., Ohmachi, T., Watanabe, M., Ikeda, M. Toxicology (1984) [Pubmed]
  29. Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach. Heijne, W.H., Stierum, R.H., Slijper, M., van Bladeren, P.J., van Ommen, B. Biochem. Pharmacol. (2003) [Pubmed]
  30. Identification of a rat liver microsomal esterase as a target protein for bromobenzene metabolites. Rombach, E.M., Hanzlik, R.P. Chem. Res. Toxicol. (1998) [Pubmed]
  31. Bromobenzene-mediated alteration in activity and electrophoretic pattern of biliverdin reductase variants in rat kidney. Huang, T.J., Maines, M.D. Mol. Pharmacol. (1990) [Pubmed]
  32. Lipidomic analysis for lipid peroxidation-derived aldehydes using gas chromatography-mass spectrometry. Kawai, Y., Takeda, S., Terao, J. Chem. Res. Toxicol. (2007) [Pubmed]
WikiGenes - Universities