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Queiroz, D.M. et al.

Dulciene M. M. Queiroz, Ivan E. B. Saraiva, Gifone A. Rocha, Andreia M. C. Rocha, Luciana I. Gomes, Fabrício F. Melo, Paulo F. S. Bittencourt,

IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood.

We evaluated whether polymorphisms in genes coding molecules linked to the innate and adaptive immune response are associated with susceptibility to Helicobacter pylori infection. IL1B-511C-->T, IL1B-31T-->C, IL1RN allele 2, IL2-330T-->G, TNFA-307G-->A, TLR2Arg677Trp, TLR2Arg753Gln, TLR4Asp299Gly, and TLR5(392STOP) polymorphisms were determined in 541 blood donors. IL2-330T-->G allele carriers had a decreased H. pylori infection risk (OR=0.63, 95% CI=0.43-0.93) after adjustment for demographic and environmental factors. Hence, we investigated whether the polymorphism is functional by evaluating IL-2 serum concentration in 150 blood donors and 100 children. IL-2 pro-inflammatory and anti-inflammatory properties were indirectly investigated by determining serum IFN-gamma and IL-10/TGF-beta levels. The polymorphism was associated with increased mean IL-2 levels in H. pylori-positive adults (2.65 pg/mL vs. 7.78 pg/mL) and children (4.19 pg/mL vs. 8.03 pg/mL). Increased IL-2 was associated with pro-inflammatory activity in adults (IFN-gamma=18.61 pg/mL vs. 25.71 pg/mL), and with anti-inflammatory activity in children (IL-10=6.99 vs. 14.17 pg/mL, TGF-beta=45.88 vs. 93.44 pg/mL) (p<10(-3) for all). In conclusion, in the context of H. pylori infection, IL2-330 T-->G polymorphism is functional and is associated with decreased risk of infection in adults.[1]

References

IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Queiroz, D.M., Saraiva, I.E., Rocha, G.A., Rocha, A.M., Gomes, L.I., Melo, F.F., Bittencourt, P.F. Microbes Infect. (2009) [Pubmed]

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