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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chronic myeloid leukemia in blast phase associated with t(3;8)(q26;q24).

We previously reported a recurrent t(3;8)(q26;q24) translocation involving EVI1 in five patients with myelodysplastic syndrome or acute myeloid leukemia. Here we report the same structural abnormality in a case of chronic myeloid leukemia in blast phase. The t(3;8)(q26;q24) occurred several months after the initial diagnosis of chronic myeloid leukemia, while the patient was being treated with a tyrosine kinase inhibitor. We confirmed rearrangement of EVI1 by fluorescence in situ hybridization assay using a dual-color break-apart probe set that spans the EVI1 region. Our findings demonstrate that, similar to other recurrent translocations involving 3q26, such as t(3;3) and t(3;21), the t(3;8)(q26;q24) is implicated not only in myelodysplastic syndrome and acute myeloid leukemia, but also in progression of chronic myeloid leukemia. These findings extend the known disease spectrum associated with this cytogenetic aberration.[1]


  1. Chronic myeloid leukemia in blast phase associated with t(3;8)(q26;q24). Lin, P., Lennon, P.A., Yin, C.C., Abruzzo, L.V. Cancer Genet. Cytogenet. (2009) [Pubmed]
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