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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Antibodies to cerebellar soluble lectin CSL in multiple sclerosis.

Cerebrospinal fluid samples from 239 patients with various neurological disorders were tested for the presence of autoantibodies to an endogenous mannose-binding protein, the cerebellar soluble lectin CSL, by means of an immunoblotting test with rat CSL as antigen. 47 of 51 patients with multiple sclerosis were positive for anti-CSL compared with 30 of 188 patients with other neurological disorders. 14 of the 30 false-positive patients were over 60 years old, an age group not typical of multiple sclerosis patients. The specificity of the test for multiple sclerosis was 85% and the sensitivity 93.5%. The possibility that CSL is an important immunological target in multiple sclerosis allows new insights into the possible causes and development of this disorder.[1]

References

  1. Antibodies to cerebellar soluble lectin CSL in multiple sclerosis. Zanetta, J.P., Warter, J.M., Kuchler, S., Marschal, P., Rumbach, L., Lehmann, S., Tranchant, C., Reeber, A., Vincendon, G. Lancet (1990) [Pubmed]
 
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