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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Age Groups

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Disease relevance of Age Groups


Psychiatry related information on Age Groups


High impact information on Age Groups

  • The capsular polysaccharide vaccine does not protect children at greatest risk (those under the age of 18 months), but a polysaccharide-protein conjugate vaccine has proved to be more immunogenic in this age group [11].
  • Regardless of the subjects' status with respect to atopy or their age group, the prevalence of asthma was closely related to the serum IgE level standardized for age and sex (P less than 0.0001), and no asthma was present in the 177 subjects with the lowest IgE levels for their age and sex (greater than 1.46 SD below the mean) [12].
  • Preprandial glucose levels on this regimen were 37+/-2 mg per deciliter (+/-S.E.M.). Basal serum insulin levels were within normal fasting levels for this age group but inappropriately elevated for the blood glucose levels [13].
  • The existing data suggest that PCOS may adversely affect or accelerate the development of an adverse cardiovascular risk profile, and even of subclinical signs of atherosclerosis, but it does not appear to lower the age of clinical presentation to a premenopausal age group [14].
  • The differences between individuals with and without ADHD were similar for males and females and across all age groups [15].

Chemical compound and disease context of Age Groups


Biological context of Age Groups

  • Blood pressure and fasting plasma glucose concentration tended to be lower among hormone users, although the differences were not statistically significant in all age groups [21].
  • In the younger age group (mean age at diagnosis <66 years), a maximum two-point LOD score of 3.65 at straight theta = .0 was observed, with D1S407 [22].
  • In both age groups, the X chromosome was micronucleated clearly more often than expected by chance, and the Y chromosome was overrepresented in micronuclei among the older men but not among the younger men [23].
  • To test this hypothesis, we determined X-inactivation ratios at the human androgen receptor locus of 295 normal females from three age groups: (1) neonates, (2) females 28 to 32 years old and, (3) females aged > or = 60 years [24].
  • The findings suggest that in this age group in a Caucasian population, not only does insulin resistance precede glucose intolerance and NIDDM, but also loss of early insulin response indicating impaired beta-cell function to be an early feature of the process culminating in diabetes [25].

Anatomical context of Age Groups


Associations of Age Groups with chemical compounds


Gene context of Age Groups

  • Two-locus analysis provides evidence of strong epistasis between 20p and the APP region, limited to the oldest age group and to those lacking ApoE4 alleles [36].
  • These studies demonstrate that TP53 gene mutations are a common mechanism for glial cell neoplasms in the 18-45-year age group but are unrelated to progression and advanced histological grade [37].
  • This interaction of EGFR with age group was statistically significant and led us to focus our further analyses on the younger patients [38].
  • There was no obvious relationship between presence of PTEN mutation and survival; however, there was a tendency for PTEN mutations to occur in older age group patients [39].
  • JNK activity was not appreciably altered by EGF treatment of cells from either age group [40].

Analytical, diagnostic and therapeutic context of Age Groups

  • Isolated Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 37 degrees C. For both age groups, spontaneous rate was decreased by acetylcholine, an effect which was reduced by atropine [41].
  • CONCLUSION: Patients with metastatic breast carcinoma who are older than 65 years tolerate the acute side effects of doxorubicin-based combination chemotherapy as well as the younger age group [42].
  • The model was stratified by age and sex and was adjusted for age within age groups, race or ethnicity, smoking, diabetes, poverty income ratio, body mass index, estrogen use, and gingival bleeding [43].
  • Serial data from 1304 examinations of 423 adult white participants in the Fels Longitudinal Study were analyzed sex-specifically in 2 age groups, 18 through 44 years and 45 to 65 years [44].
  • Thirty and 60 min after the painful stimulus of the venipuncture, plasma cortisol increased significantly (P less than 0.0005), reaching a maximum increase up to 458 +/- 50, 392 +/- 66, and 455 +/- 97 nmol/L in each age group, respectively [45].


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  10. Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation. Joseph, J.A., Bartus, R.T., Clody, D., Morgan, D., Finch, C., Beer, B., Sesack, S. Neurobiol. Aging (1983) [Pubmed]
  11. A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. Eskola, J., Käyhty, H., Takala, A.K., Peltola, H., Rönnberg, P.R., Kela, E., Pekkanen, E., McVerry, P.H., Mäkelä, P.H. N. Engl. J. Med. (1990) [Pubmed]
  12. Association of asthma with serum IgE levels and skin-test reactivity to allergens. Burrows, B., Martinez, F.D., Halonen, M., Barbee, R.A., Cline, M.G. N. Engl. J. Med. (1989) [Pubmed]
  13. Hypoglycemia of infancy and nesidioblastosis. Studies with somatostatin. Hirsch, H.J., Loo, S., Evans, N., Crigler, J.F., Filler, R.M., Gabbay, K.H. N. Engl. J. Med. (1977) [Pubmed]
  14. Polycystic ovary syndrome and cardiovascular disease: a premature association? Legro, R.S. Endocr. Rev. (2003) [Pubmed]
  15. Use and costs of medical care for children and adolescents with and without attention-deficit/hyperactivity disorder. Leibson, C.L., Katusic, S.K., Barbaresi, W.J., Ransom, J., O'Brien, P.C. JAMA (2001) [Pubmed]
  16. Correlation between the biliary excretion of ouabain and the lateral mobility of hepatocyte plasma membrane proteins in the rat--the effects of age and spironolactone pretreatment. Kitani, K., Zsolnai-Nagy, I., Kanai, S., Sato, Y., Ohta, M. Hepatology (1988) [Pubmed]
  17. Clinical experience and rationale for angiotensin-converting enzyme inhibition with lisinopril as the initial treatment for hypertension in older patients. Pool, J.L., Nelson, E.B., Taylor, A.A. Am. J. Med. (1988) [Pubmed]
  18. Efficacy, safety, and quality-of-life assessment of captopril antihypertensive therapy in clinical practice. Schoenberger, J.A., Testa, M., Ross, A.D., Brennan, W.K., Bannon, J.A. Arch. Intern. Med. (1990) [Pubmed]
  19. Abnormal lipid concentrations in cystic fibrosis. Figueroa, V., Milla, C., Parks, E.J., Schwarzenberg, S.J., Moran, A. Am. J. Clin. Nutr. (2002) [Pubmed]
  20. Effect of vitamin A supplementation on the growth of young children in northern Ghana. Kirkwood, B.R., Ross, D.A., Arthur, P., Morris, S.S., Dollimore, N., Binka, F.N., Shier, R.P., Gyapong, J.O., Addy, H.A., Smith, P.G. Am. J. Clin. Nutr. (1996) [Pubmed]
  21. Heart disease risk factors and hormone use in postmenopausal women. Barrett-Connor, E., Brown, W.V., Turner, J., Austin, M., Criqui, M.H. JAMA (1979) [Pubmed]
  22. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Gibbs, M., Stanford, J.L., McIndoe, R.A., Jarvik, G.P., Kolb, S., Goode, E.L., Chakrabarti, L., Schuster, E.F., Buckley, V.A., Miller, E.L., Brandzel, S., Li, S., Hood, L., Ostrander, E.A. Am. J. Hum. Genet. (1999) [Pubmed]
  23. Age-dependent inclusion of sex chromosomes in lymphocyte micronuclei of man. Catalán, J., Autio, K., Kuosma, E., Norppa, H. Am. J. Hum. Genet. (1998) [Pubmed]
  24. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., Gilliland, D.G. Blood (1996) [Pubmed]
  25. Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men. Eriksson, K.F., Lindgärde, F. Diabetologia (1996) [Pubmed]
  26. Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70. Goodwin, J.S., Messner, R.P. J. Clin. Invest. (1979) [Pubmed]
  27. Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. Brannon, T.S., North, A.J., Wells, L.B., Shaul, P.W. J. Clin. Invest. (1994) [Pubmed]
  28. Neurotensin stimulates growth of colonic mucosa in young and aged rats. Evers, B.M., Izukura, M., Chung, D.H., Parekh, D., Yoshinaga, K., Greeley, G.H., Uchida, T., Townsend, C.M., Thompson, J.C. Gastroenterology (1992) [Pubmed]
  29. The pulmonary vascular bed in patients with complete transposition of the great arteries. Clarkson, P.M., Neutze, J.M., Wardill, J.C., Barratt-Boyes, B.G. Circulation (1976) [Pubmed]
  30. Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity. del Balzo, U., Rosen, M.R., Malfatto, G., Kaplan, L.M., Steinberg, S.F. Circ. Res. (1990) [Pubmed]
  31. Cholesterol and coronary heart disease. Future directions. Grundy, S.M. JAMA (1990) [Pubmed]
  32. Valproic acid therapy in childhood epilepsy. Coulter, D.L., Wu, H., Allen, R.J. JAMA (1980) [Pubmed]
  33. Regulation of lipolysis during the neonatal period. Importance of thyrotropin. Marcus, C., Ehrén, H., Bolme, P., Arner, P. J. Clin. Invest. (1988) [Pubmed]
  34. Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. Howe, G.R., Benito, E., Castelleto, R., Cornée, J., Estève, J., Gallagher, R.P., Iscovich, J.M., Deng-ao, J., Kaaks, R., Kune, G.A. J. Natl. Cancer Inst. (1992) [Pubmed]
  35. A case-control study of dietary and nondietary factors in ovarian cancer. Byers, T., Marshall, J., Graham, S., Mettlin, C., Swanson, M. J. Natl. Cancer Inst. (1983) [Pubmed]
  36. A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region. Olson, J.M., Goddard, K.A., Dudek, D.M. Am. J. Hum. Genet. (2002) [Pubmed]
  37. Alterations of the TP53 gene in human gliomas. Rasheed, B.K., McLendon, R.E., Herndon, J.E., Friedman, H.S., Friedman, A.H., Bigner, D.D., Bigner, S.H. Cancer Res. (1994) [Pubmed]
  38. Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Simmons, M.L., Lamborn, K.R., Takahashi, M., Chen, P., Israel, M.A., Berger, M.S., Godfrey, T., Nigro, J., Prados, M., Chang, S., Barker, F.G., Aldape, K. Cancer Res. (2001) [Pubmed]
  39. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Rasheed, B.K., Stenzel, T.T., McLendon, R.E., Parsons, R., Friedman, A.H., Friedman, H.S., Bigner, D.D., Bigner, S.H. Cancer Res. (1997) [Pubmed]
  40. Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes. Liu, Y., Guyton, K.Z., Gorospe, M., Xu, Q., Kokkonen, G.C., Mock, Y.D., Roth, G.S., Holbrook, N.J. J. Biol. Chem. (1996) [Pubmed]
  41. Effects of acetylcholine on the ventricular specialized conducting system of neonatal and adult dogs. Danilo, P., Rosen, M.R., Hordof, A.J. Circ. Res. (1978) [Pubmed]
  42. Doxorubicin-based chemotherapy in elderly patients with metastatic breast cancer. Tolerance and outcome. Ibrahim, N.K., Frye, D.K., Buzdar, A.U., Walters, R.S., Hortobagyi, G.N. Arch. Intern. Med. (1996) [Pubmed]
  43. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Dietrich, T., Joshipura, K.J., Dawson-Hughes, B., Bischoff-Ferrari, H.A. Am. J. Clin. Nutr. (2004) [Pubmed]
  44. Serial changes in body composition throughout adulthood and their relationships to changes in lipid and lipoprotein levels. The Fels Longitudinal Study. Siervogel, R.M., Wisemandle, W., Maynard, L.M., Guo, S.S., Roche, A.F., Chumlea, W.C., Towne, B. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  45. A simple stress test for the evaluation of hypothalamic-pituitary-adrenal axis during the first 6 months of life. Mantagos, S., Koulouris, A., Vagenakis, A. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
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