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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate.

Polymyxin B sulfate diminished the endotoxin-mediated release of human blood neutrophil lysosomal enzymes. Similarly, this antibiotic reduced the endotoxin-induced increase in the neutrophil hexose monophosphate pathway activity as measured by the release of 14CO2 from [l-14C]glucose. Although these effects were seen with therapeutically attainable levels of polymyxin B sulfate, they could not be demonstrated when the cell-endotoxin interaction preceded treatment with polymyxin B sulfate.[1]

References

  1. Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate. Bannatyne, R.M., Harnett, N.M., Lee, K.Y., Biggar, W.D. J. Infect. Dis. (1977) [Pubmed]
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