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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies.

In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insulin-binding antibodies (in two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulin and suppressed C-peptide immunoreactivity represents a triad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide and free insulin permitted patients with high titers of insulin antibodies, including those with a history of insulin-treated diabetes, to be studied and diagnosed in a way similar to that in subjects who had no circulating insulin antibodies.[1]

References

  1. Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies. Scarlett, J.A., Mako, M.E., Rubenstein, A.H., Blix, P.M., Goldman, J., Horwitz, D.L., Tager, H., Jaspan, J.B., Stjernholm, M.R., Olefsky, J.M. N. Engl. J. Med. (1977) [Pubmed]
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