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Marchiori, E. et al.

Edson Marchiori, Gláucia Zanetti, Bruno Hochhegger, Rosana Souza Rodrigues, Cristina Asvolinsque Pantaleão Fontes, Luiz Felipe Nobre, Alexandre Dias Mançano, Gustavo Meirelles, Klaus Loureiro Irion,

High-resolution computed tomography findings from adult patients with Influenza A (H1N1) virus-associated pneumonia.

OBJECTIVE: The aim of this study was to assess the high-resolution computed tomography (HRCT) findings at presentation in patients diagnosed with Influenza A (H1N1) virus-associated pneumonia. MATERIALS AND METHODS: We reviewed the HRCT findings from 20 patients diagnosed with Influenza A (H1N1) and compared their HRCT scans with chest radiographs, obtained on the same day. The imaging studies were obtained 4-9 days after the onset of symptoms. The patients included 11 men and 9 women (ages 24-62 years; mean 42.7 years). All patients had a body temperature greater than 100.4 degrees F (>38 degrees C), tachypnea, and cough. Other common symptoms included diarrhea (60%) and sore throat (30%). The radiographs and HRCT scans were reviewed independently by two observers who reached a consensus decision. RESULTS: The predominant HRCT findings consisted of bilateral ground-glass opacities (n=12), bilateral areas of consolidation (n=2), or a mixed bilateral pattern of ground-glass opacities and areas of consolidation (n=6). The abnormalities were bilateral in all of the 20 patients, had a predominantly sub-pleural distribution in 13 patients, and had a random distribution in the remaining 7 patients. The predominant radiographic findings were consolidations. Normal radiographs were found in 4 out of the 20 patients. CONCLUSION: HRCT may reveal parenchymal abnormalities in patients with Influenza A (H1N1) infection who have normal findings on radiographs. The predominant HRCT findings were bilateral, peripheral, ground-glass opacities and/or bilateral areas of consolidation. The patients who presented consolidations had more severe clinical course.[1]

References

High-resolution computed tomography findings from adult patients with Influenza A (H1N1) virus-associated pneumonia. Marchiori, E., Zanetti, G., Hochhegger, B., Rodrigues, R.S., Fontes, C.A., Nobre, L.F., Mançano, A.D., Meirelles, G., Irion, K.L. Eur. J. Radiol (2010) [Pubmed]

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