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Disease relevance of Pharyngitis


High impact information on Pharyngitis


Chemical compound and disease context of Pharyngitis

  • To evaluate this activity of caffeine, we used new study methods in a randomized controlled trial on patients with acute sore throat due to tonsillopharyngitis [11].
  • Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model [12].
  • We conclude that the sore throat pain model is a sensitive assay for identification of the activity of oral analgesic drugs in children and that ibuprofen is an effective analgesic in children [13].
  • Sore throat and hoarseness are usually unrelated to yeast infection in patients using triamcinolone acetonide aerosol [14].
  • With the exception of methacholine, all substances caused symptoms of rhinorrhea, congestion, and sore throat [15].

Biological context of Pharyngitis

  • Three classes of macrolide resistance phenotypes and three different erythromycin resistance determinants were found among 127 erythromycin-resistant group A streptococcal (GAS) isolates recovered from 355 (35.8%) pediatric pharyngitis patients in Rome, Italy [16].
  • Being as efficacious as penicillin and having the advantages over erythromycin of once-daily dosing and the lack of drug interactions, dirithromycin is an alternative to penicillin in the treatment of streptococcal pharyngitis for patients 12 years of age and older [17].
  • Preliminary sequencing of the genome of an erythromycin-resistant serotype M6 clone that was responsible for a pharyngitis outbreak in Pittsburgh, Pennsylvania, was conducted to determine the structure of the genetic element containing the mefA gene, which encodes a macrolide efflux protein [18].
  • The Directigen 1-2-3 Group A Strep Test (DGAST; BBL Microbiology Systems, Cockeysville, Md.) was compared with conventional culture procedures on Trypticase soy agar with 5% sheep blood (BBL) and Selective Streptococcal Agar (ssA; BBL) for detection of group A beta-hemolytic streptococci (GABHS) for 1,006 patients complaining of sore throat [19].
  • The predicted amino acid sequences of the two pharyngitis strains were identical and were 88% homologous to the amino acid sequence of a group G M-protein gene [20].

Anatomical context of Pharyngitis


Gene context of Pharyngitis

  • Clindamycin in the treatment of an outbreak of streptococcal pharyngitis in a kibbutz due to beta-lactamase producing organisms [26].
  • A study of H2 receptor antagonists in the treatment of chronic intractable pharyngitis [27].
  • In a controlled study of 75 patients suffering from chronic pharyngitis: 30 were treated with H2-receptor antagonist, 30 with H1-receptor antagonist, local decongestants and antiseptic gargles: and 15 treated with alum, salt or Dispirin gargles acted as controls [27].
  • The typical triad in our series was: pharyngitis, a tender/swollen neck, and noncavitating pulmonary infiltrates [28].
  • Paired acute and convalescent sera from patients with streptococcal pharyngitis possessed significantly higher levels of anti-SCP IgG than did sera from healthy individuals [29].

Analytical, diagnostic and therapeutic context of Pharyngitis


  1. Serum opacity factor is a major fibronectin-binding protein and a virulence determinant of M type 2 Streptococcus pyogenes. Courtney, H.S., Hasty, D.L., Li, Y., Chiang, H.C., Thacker, J.L., Dale, J.B. Mol. Microbiol. (1999) [Pubmed]
  2. Laparoscopic antireflux surgery for supraesophageal complications of gastroesophageal reflux disease. Klaus, A., Swain, J.M., Hinder, R.A. Am. J. Med. (2001) [Pubmed]
  3. Cefetamet pivoxil in the treatment of pharyngitis/tonsillitis in children and adults. Guggenbichler, J.P. Drugs (1994) [Pubmed]
  4. Emergence of group A streptococcus strains with different mechanisms of macrolide resistance. Bingen, E., Leclercq, R., Fitoussi, F., Brahimi, N., Malbruny, B., Deforche, D., Cohen, R. Antimicrob. Agents Chemother. (2002) [Pubmed]
  5. Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils. Park, H.S., Cleary, P.P. Infect. Immun. (2005) [Pubmed]
  6. Resistance to erythromycin in group A streptococci. Seppälä, H., Nissinen, A., Järvinen, H., Huovinen, S., Henriksson, T., Herva, E., Holm, S.E., Jahkola, M., Katila, M.L., Klaukka, T. N. Engl. J. Med. (1992) [Pubmed]
  7. Penicillin V for group A streptococcal pharyngotonsillitis. A randomized trial of seven vs ten days' therapy. Schwartz, R.H., Wientzen, R.L., Pedreira, F., Feroli, E.J., Mella, G.W., Guandolo, V.L. JAMA (1981) [Pubmed]
  8. Streptococcal pharyngitis in children. A comparison of four treatment schedules with intramuscular penicillin G benzathine. Bass, J.W., Crast, F.W., Knowles, C.R., Onufer, C.N. JAMA (1976) [Pubmed]
  9. New York State primary care physicians' attitudes to community pharmacists' clinical services. Bailie, G.R., Romeo, B. Arch. Intern. Med. (1996) [Pubmed]
  10. A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis. Hooton, T.M. Am. J. Med. (1991) [Pubmed]
  11. Caffeine as an analgesic adjuvant. A double-blind study comparing aspirin with caffeine to aspirin and placebo in patients with sore throat. Schachtel, B.P., Fillingim, J.M., Lane, A.C., Thoden, W.R., Baybutt, R.I. Arch. Intern. Med. (1991) [Pubmed]
  12. Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model. Schachtel, B.P., Homan, H.D., Gibb, I.A., Christian, J. Clin. Pharmacol. Ther. (2002) [Pubmed]
  13. A placebo-controlled model for assaying systemic analgesics in children. Schachtel, B.P., Thoden, W.R. Clin. Pharmacol. Ther. (1993) [Pubmed]
  14. Oropharyngeal candidiasis in patients treated with triamcinolone acetonide aerosol. Pingleton, W.W., Bone, R.C., Kerby, G.R., Ruth, W.E. J. Allergy Clin. Immunol. (1977) [Pubmed]
  15. Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. Doyle, W.J., Boehm, S., Skoner, D.P. J. Allergy Clin. Immunol. (1990) [Pubmed]
  16. Erythromycin-resistant pharyngeal isolates of Streptococcus pyogenes recovered in Italy. Dicuonzo, G., Fiscarelli, E., Gherardi, G., Lorino, G., Battistoni, F., Landi, S., De Cesaris, M., Petitti, T., Beall, B. Antimicrob. Agents Chemother. (2002) [Pubmed]
  17. Comparison of dirithromycin and penicillin for treatment of streptococcal pharyngitis. Watkins, V.S., Smietana, M., Conforti, P.M., Sides, G.D., Huck, W. Antimicrob. Agents Chemother. (1997) [Pubmed]
  18. Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus. Banks, D.J., Porcella, S.F., Barbian, K.D., Martin, J.M., Musser, J.M. J. Infect. Dis. (2003) [Pubmed]
  19. Comparison of the Directigen 1-2-3 Group A Strep Test with culture for detection of group A beta-hemolytic streptococci. Huck, W., Reed, B.D., French, T., Mitchell, R.S. J. Clin. Microbiol. (1989) [Pubmed]
  20. M proteins of group C streptococci isolated from patients with acute pharyngitis. Bisno, A.L., Collins, C.M., Turner, J.C. J. Clin. Microbiol. (1996) [Pubmed]
  21. Potential mechanisms for failure to eradicate group A streptococci from the pharynx. Gerber, M.A., Tanz, R.R., Kabat, W., Bell, G.L., Siddiqui, B., Lerer, T.J., Lepow, M.L., Kaplan, E.L., Shulman, S.T. Pediatrics (1999) [Pubmed]
  22. Isolation and characterization of a cold-sensitive strain of coxsackievirus A10. Itagaki, A., Kamahora, T., Kurimura, T. J. Gen. Virol. (1987) [Pubmed]
  23. Clarithromycin vs penicillin in the treatment of streptococcal pharyngitis. Schrock, C.G. The Journal of family practice. (1992) [Pubmed]
  24. Gargling with sodium azulene sulfonate reduces the postoperative sore throat after intubation of the trachea. Ogata, J., Minami, K., Horishita, T., Shiraishi, M., Okamoto, T., Terada, T., Sata, T. Anesth. Analg. (2005) [Pubmed]
  25. Characteristics of prostaglandin induced cough in man. Costello, J.F., Dunlop, L.S., Gardiner, P.J. British journal of clinical pharmacology. (1985) [Pubmed]
  26. Clindamycin in the treatment of an outbreak of streptococcal pharyngitis in a kibbutz due to beta-lactamase producing organisms. Raz, R., Hamburger, S., Flatau, E. Journal of chemotherapy (Florence, Italy) (1990) [Pubmed]
  27. A study of H2 receptor antagonists in the treatment of chronic intractable pharyngitis. Zaidi, S.H. JPMA. The Journal of the Pakistan Medical Association. (1990) [Pubmed]
  28. The evolution of Lemierre syndrome: report of 2 cases and review of the literature. Chirinos, J.A., Lichtstein, D.M., Garcia, J., Tamariz, L.J. Medicine (Baltimore) (2002) [Pubmed]
  29. The human antibody response to streptococcal C5a peptidase. O'Connor, S.P., Darip, D., Fraley, K., Nelson, C.M., Kaplan, E.L., Cleary, P.P. J. Infect. Dis. (1991) [Pubmed]
  30. Immunodiffusion and agglutination tests for Candida in patients with neoplastic disease: inconsistent correlation of results with invasive infections. Filice, G., Yu, B., Armstrong, D. J. Infect. Dis. (1977) [Pubmed]
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