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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Body Temperature

 
 
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Disease relevance of Body Temperature

  • METHODS: The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33 degrees C), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia [1].
  • Here we show that Mstn-null mice have a significant reduction in fat accumulation with increasing age compared with wild-type littermates, even in the setting of normal food intake (relative to body weight), normal body temperature, and a slightly decreased resting metabolic rate [2].
  • Hypothermia (body temperature, 30 degrees C to 31 degrees C) did not affect IA/AR (67 +/- 3%, n = 11) in control animals but enhanced protection by 15-minute CAO (IA/AR = 22 +/- 3%, n = 8), whereas protection by 15-minute MAO (IA/AR = 44 +/- 5%, n = 11, P < .001) was minimally enhanced [3].
  • A case of allergic rash associated with malignant hyperthermia (body temperature of 41 C) occurred in a patient who had been taking 400 mg of thioridazine hydrochloride (Mellaril) daily for two days [4].
  • Under these conditions, we found no significant difference between the women with fibromyalgia and control women in the circadian amplitude or phase of rhythms of melatonin, cortisol, and core body temperature [5].
 

Psychiatry related information on Body Temperature

 

High impact information on Body Temperature

  • Since it was immortalized using the temperature-sensitive allele tsA58 of SV40 large T antigen, these cells grow continuously at 33 degrees C, but not at 39 degrees C, the body temperature of rodents [11].
  • In addition, disruption of the AT2 gene attenuated exploratory behaviour and lowered body temperature [12].
  • The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee) [13].
  • C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature [14].
  • The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion [15].
 

Chemical compound and disease context of Body Temperature

 

Biological context of Body Temperature

 

Anatomical context of Body Temperature

 

Associations of Body Temperature with chemical compounds

 

Gene context of Body Temperature

 

Analytical, diagnostic and therapeutic context of Body Temperature

References

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