The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Body Temperature

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Body Temperature

  • METHODS: The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33 degrees C), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia [1].
  • Here we show that Mstn-null mice have a significant reduction in fat accumulation with increasing age compared with wild-type littermates, even in the setting of normal food intake (relative to body weight), normal body temperature, and a slightly decreased resting metabolic rate [2].
  • Hypothermia (body temperature, 30 degrees C to 31 degrees C) did not affect IA/AR (67 +/- 3%, n = 11) in control animals but enhanced protection by 15-minute CAO (IA/AR = 22 +/- 3%, n = 8), whereas protection by 15-minute MAO (IA/AR = 44 +/- 5%, n = 11, P < .001) was minimally enhanced [3].
  • A case of allergic rash associated with malignant hyperthermia (body temperature of 41 C) occurred in a patient who had been taking 400 mg of thioridazine hydrochloride (Mellaril) daily for two days [4].
  • Under these conditions, we found no significant difference between the women with fibromyalgia and control women in the circadian amplitude or phase of rhythms of melatonin, cortisol, and core body temperature [5].

Psychiatry related information on Body Temperature


High impact information on Body Temperature

  • Since it was immortalized using the temperature-sensitive allele tsA58 of SV40 large T antigen, these cells grow continuously at 33 degrees C, but not at 39 degrees C, the body temperature of rodents [11].
  • In addition, disruption of the AT2 gene attenuated exploratory behaviour and lowered body temperature [12].
  • The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee) [13].
  • C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature [14].
  • The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion [15].

Chemical compound and disease context of Body Temperature


Biological context of Body Temperature


Anatomical context of Body Temperature


Associations of Body Temperature with chemical compounds


Gene context of Body Temperature


Analytical, diagnostic and therapeutic context of Body Temperature


  1. Lack of effect of induction of hypothermia after acute brain injury. Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Muizelaar, J.P., Wagner, F.C., Marion, D.W., Luerssen, T.G., Chesnut, R.M., Schwartz, M. N. Engl. J. Med. (2001) [Pubmed]
  2. Suppression of body fat accumulation in myostatin-deficient mice. McPherron, A.C., Lee, S.J. J. Clin. Invest. (2002) [Pubmed]
  3. Myocardial protection by brief ischemia in noncardiac tissue. Gho, B.C., Schoemaker, R.G., van den Doel, M.A., Duncker, D.J., Verdouw, P.D. Circulation (1996) [Pubmed]
  4. Malignant hyperthermia. An allergic reaction to thioridazine therapy. Haberman, M.L. Arch. Intern. Med. (1978) [Pubmed]
  5. Circadian rhythms of women with fibromyalgia. Klerman, E.B., Goldenberg, D.L., Brown, E.N., Maliszewski, A.M., Adler, G.K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  6. Effects of clozapine and fluphenazine treatment on responses to m-chlorophenylpiperazine infusions in schizophrenia. Owen, R.R., Gutierrez-Esteinou, R., Hsiao, J., Hadd, K., Benkelfat, C., Lawlor, B.A., Murphy, D.L., Pickar, D. Arch. Gen. Psychiatry (1993) [Pubmed]
  7. Cortisol suppression and circadian rhythm in endogenous depression: a preliminary report. Lee, M.A., Taylor, M.A. Biol. Psychiatry (1983) [Pubmed]
  8. Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Huitron-Resendiz, S., Sanchez-Alavez, M., Wills, D.N., Cravatt, B.F., Henriksen, S.J. Sleep. (2004) [Pubmed]
  9. Clorgyline-induced reduction in body temperature and its relationship to vigilance states in Syrian hamsters. Gao, B., Duncan, W.C., Wehr, T.A. Neuropsychopharmacology (1991) [Pubmed]
  10. Compensatory sleep responses to wakefulness induced by the dopamine autoreceptor antagonist (-)DS121. Olive, M.F., Seidel, W.F., Edgar, D.M. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  11. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Renfranz, P.J., Cunningham, M.G., McKay, R.D. Cell (1991) [Pubmed]
  12. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Ichiki, T., Labosky, P.A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B.L., Inagami, T. Nature (1995) [Pubmed]
  13. Extraocular circadian phototransduction in humans. Campbell, S.S., Murphy, P.J. Science (1998) [Pubmed]
  14. Effects of the obese gene product on body weight regulation in ob/ob mice. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., Collins, F. Science (1995) [Pubmed]
  15. Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Czeisler, C.A., Allan, J.S., Strogatz, S.H., Ronda, J.M., Sánchez, R., Ríos, C.D., Freitag, W.O., Richardson, G.S., Kronauer, R.E. Science (1986) [Pubmed]
  16. The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. Makabe-Kobayashi, Y., Hori, Y., Adachi, T., Ishigaki-Suzuki, S., Kikuchi, Y., Kagaya, Y., Shirato, K., Nagy, A., Ujike, A., Takai, T., Watanabe, T., Ohtsu, H. J. Allergy Clin. Immunol. (2002) [Pubmed]
  17. Vitamin A status in acute exacerbations of cystic fibrosis. Duggan, C., Colin, A.A., Agil, A., Higgins, L., Rifai, N. Am. J. Clin. Nutr. (1996) [Pubmed]
  18. Compromised neuroimmune status in rats with experimental colitis. Boissé, L., Van Sickle, M.D., Sharkey, K.A., Pittman, Q.J. J. Physiol. (Lond.) (2003) [Pubmed]
  19. 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. Orio, L., O'Shea, E., Sanchez, V., Pradillo, J.M., Escobedo, I., Camarero, J., Moro, M.A., Green, A.R., Colado, M.I. J. Neurochem. (2004) [Pubmed]
  20. Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats. Long, N.C., Morimoto, A., Nakamori, T., Yamashiro, O., Murakami, N. J. Physiol. (Lond.) (1991) [Pubmed]
  21. Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection? Fuller, P.M., Jones, T.A., Jones, S.M., Fuller, C.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  22. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. Dijk, D.J., Czeisler, C.A. J. Neurosci. (1995) [Pubmed]
  23. Role of the lateral preoptic area in sleep-related erectile mechanisms and sleep generation in the rat. Schmidt, M.H., Valatx, J.L., Sakai, K., Fort, P., Jouvet, M. J. Neurosci. (2000) [Pubmed]
  24. Investigation of the abuse liability of buspirone in alcohol-dependent patients. Griffith, J.D., Jasinski, D.R., Casten, G.P., McKinney, G.R. Am. J. Med. (1986) [Pubmed]
  25. Standardization of tissue culture conditions for spontaneous thymidine-2-14C incorporation by unstimulated normal human peripheral lymphocytes: circadian rhythm of DNA synthesis. Carter, J.B., Barr, G.D., Levin, A.S., Byers, V.S., Ponce, B., Fudenberg, H.H., German, D.F. J. Allergy Clin. Immunol. (1975) [Pubmed]
  26. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. Togashi, K., Hara, Y., Tominaga, T., Higashi, T., Konishi, Y., Mori, Y., Tominaga, M. EMBO J. (2006) [Pubmed]
  27. Effect of first treatment with aminobisphosphonates pamidronate and ibandronate on circulating lymphocyte subpopulations. Pecherstorfer, M., Jilch, R., Sauty, A., Horn, E., Keck, A.V., Zimmer-Roth, I., Thiebaud, D. J. Bone Miner. Res. (2000) [Pubmed]
  28. Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. Schweitzer, D.H., Oostendorp-van de Ruit, M., Van der Pluijm, G., Löwik, C.W., Papapoulos, S.E. J. Bone Miner. Res. (1995) [Pubmed]
  29. Intracoronary ethyl alcohol or phenol injection ablates aconitine-induced ventricular tachycardia in dogs. Inoue, H., Waller, B.F., Zipes, D.P. J. Am. Coll. Cardiol. (1987) [Pubmed]
  30. Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. Alkana, R.L., Finn, D.A., Galleisky, G.G., Syapin, P.J., Malcolm, R.D. Science (1985) [Pubmed]
  31. Chronotypic action of theophylline and of pentobarbital as circadian zeitgebers in the rat. Ehret, C.F., Potter, V.R., Dobra, K.W. Science (1975) [Pubmed]
  32. Fever: effect of drug-induced antipyresis on survival. Bernheim, H.A., Kluger, M.J. Science (1976) [Pubmed]
  33. Thyrotropin-releasing hormone effects in the central nervous system: dependence on arousal state. Stanton, T.L., Bechman, A.L., Winokur, A. Science (1981) [Pubmed]
  34. Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Chae, J.J., Komarow, H.D., Cheng, J., Wood, G., Raben, N., Liu, P.P., Kastner, D.L. Mol. Cell (2003) [Pubmed]
  35. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Ste Marie, L., Miura, G.I., Marsh, D.J., Yagaloff, K., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  36. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. D'Agostino, D., Cordle, R.A., Kullman, J., Erlanson-Albertsson, C., Muglia, L.J., Lowe, M.E. J. Biol. Chem. (2002) [Pubmed]
  37. Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system. Mondal, M.S., Date, Y., Murakami, N., Toshinai, K., Shimbara, T., Kangawa, K., Nakazato, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  38. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Hunter, J.C., Fontana, D.J., Hedley, L.R., Jasper, J.R., Lewis, R., Link, R.E., Secchi, R., Sutton, J., Eglen, R.M. Br. J. Pharmacol. (1997) [Pubmed]
  39. Differential expression of tumor necrosis factor receptor subtypes on leukocytes in systemic inflammatory response syndrome. Hübl, W., Wolfbauer, G., Streicher, J., Andert, S., Stanek, G., Fitzal, S., Bayer, P.M. Crit. Care Med. (1999) [Pubmed]
  40. Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. Li, X.M., Zhang, T.F., Huang, C.K., Srivastava, K., Teper, A.A., Zhang, L., Schofield, B.H., Sampson, H.A. J. Allergy Clin. Immunol. (2001) [Pubmed]
  41. Hypothalamic interaction between macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta in rats: a new level for fever control? Miñano, F.J., Fernández-Alonso, A., Myers, R.D., Sancibrián, M. J. Physiol. (Lond.) (1996) [Pubmed]
  42. The effect on deep body temperature of the intraventricular injection of two prostaglandin endoperoxide analogues [proceedings]. Cremades-Campos, A., Milton, A.S. J. Physiol. (Lond.) (1978) [Pubmed]
  43. The hypothermic effect of melatonin on core body temperature: is more better? Dawson, D., Gibbon, S., Singh, P. J. Pineal Res. (1996) [Pubmed]
  44. Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus. Inglefield, J.R., Perry, J.M., Schwartz, R.D. Hippocampus. (1995) [Pubmed]
WikiGenes - Universities