Diphenylhydantoin-induced hypogammaglobulinemia in a patient infected with human immunodeficiency virus.
A case is reported of reversible panhypogammaglobulinemia in a human immunodeficiency virus (HIV)-infected patient. Onset and resolution were temporally correlated with initiation and termination, respectively, of diphenylhydantoin therapy for a possible seizure. A rapid alteration in peripheral T-cell subpopulations was also noted in association with diphenylhydantoin administration. This case is compared with previous reports of diphenylhydantoin-associated hypogammaglobulinemia in non-HIV-infected patients. In addition, the case is discussed with regard to possible deleterious effects associated with the use of diphenylhydantoin as therapy for HIV-associated seizures or as an antiretroviral agent in HIV disease.[1]References
- Diphenylhydantoin-induced hypogammaglobulinemia in a patient infected with human immunodeficiency virus. Britigan, B.E. Am. J. Med. (1991) [Pubmed]
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