Chemical Compound Review:
Dilantin 5,5-diphenylimidazolidine- 2,4-dione
Synonyms:
Epanutin, Fenitoin, Hydantol, Antisacer, Difenin, ...
- Predisposition to phenytoin hepatotoxicity assessed in vitro. Spielberg, S.P., Gordon, G.B., Blake, D.A., Goldstein, D.A., Herlong, H.F. N. Engl. J. Med. (1981)
- Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. Mattson, R.H., Cramer, J.A., Collins, J.F., Smith, D.B., Delgado-Escueta, A.V., Browne, T.R., Williamson, P.D., Treiman, D.M., McNamara, J.O., McCutchen, C.B. N. Engl. J. Med. (1985)
- A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. Mattson, R.H., Cramer, J.A., Collins, J.F. N. Engl. J. Med. (1992)
- Images in clinical medicine. Gingival hyperplasia induced by phenytoin. Sharma, S., Dasroy, S.K. N. Engl. J. Med. (2000)
- Cardiac arrhythmias after small iv dose of phenytoin. Barron, S.A. N. Engl. J. Med. (1976)
- Basis for recurring ventricular fibrillation in the absence of coronary heart disease and its management. Lown, B., Temte, J.V., Reich, P., Gaughan, C., Regestein, Q., Hal, H. N. Engl. J. Med. (1976)
- Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. Scolnik, D., Nulman, I., Rovet, J., Gladstone, D., Czuchta, D., Gardner, H.A., Gladstone, R., Ashby, P., Weksberg, R., Einarson, T. JAMA (1994)
- Phenytoin-induced methadone withdrawal. Tong, T.G., Pond, S.M., Kreek, M.J., Jaffery, N.F., Benowitz, N.L. Ann. Intern. Med. (1981)
- Phenytoin as an antimanic anticonvulsant: a controlled study. Mishory, A., Yaroslavsky, Y., Bersudsky, Y., Belmaker, R.H. The American journal of psychiatry. (2000)
- Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Willow, M., Kuenzel, E.A., Catterall, W.A. Mol. Pharmacol. (1984)
- Phenobarbital compared with phenytoin for the treatment of neonatal seizures. Painter, M.J., Scher, M.S., Stein, A.D., Armatti, S., Wang, Z., Gardiner, J.C., Paneth, N., Minnigh, B., Alvin, J. N. Engl. J. Med. (1999)
- A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. Lucas, M.J., Leveno, K.J., Cunningham, F.G. N. Engl. J. Med. (1995)
- Magnesium sulfate versus phenytoin for the prevention of eclampsia. Friedman, M.N. N. Engl. J. Med. (1995)
- Lack of efficacy of phenytoin in recessive dystrophic epidermolysis bullosa. Epidermolysis Bullosa Study Group. Caldwell-Brown, D., Stern, R.S., Lin, A.N., Carter, D.M. N. Engl. J. Med. (1992)
- A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. Temkin, N.R., Dikmen, S.S., Wilensky, A.J., Keihm, J., Chabal, S., Winn, H.R. N. Engl. J. Med. (1990)
- Magnesium sulfate versus phenytoin for the prevention of eclampsia. Duggan, K., Macdonald, G. N. Engl. J. Med. (1995)
- The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Curran, P.G., DeGroot, L.J. Endocr. Rev. (1991)
- Status epilepticus. The role of intravenous phenytoin. Cloyd, J.C., Gumnit, R.J., McLain, L.W. JAMA (1980)
- Intoxication caused by interaction of chloramphenicol and phenytoin. Rose, J.Q., Choi, H.K., Schentag, J.J., Kinkel, W.R., Jusko, W.J. JAMA (1977)
- Cancer among epileptic patients exposed to anticonvulsant drugs. Olsen, J.H., Boice, J.D., Jensen, J.P., Fraumeni, J.F. J. Natl. Cancer Inst. (1989)
- Maternal hyperoxia greatly reduces the incidence of phenytoin-induced cleft lip and palate in A/J mice. Millicovsky, G., Johnston, M.C. Science (1981)
- Decreased serum protein binding of phenytoin in late pregnancy. Ruprah, M., Perucca, E., Richens, A. Lancet (1980)
- Letter: Bioavailability of phenytoin. Tammisto, P., Kauko, K., Viukari, M. Lancet (1976)
- Genetic predisposition to phenytoin-induced birth defects. Strickler, S.M., Dansky, L.V., Miller, M.A., Seni, M.H., Andermann, E., Spielberg, S.P. Lancet (1985)
- Halothane hepatitis. Detection of a constitutional susceptibility factor. Farrell, G., Prendergast, D., Murray, M. N. Engl. J. Med. (1985)
- Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice. Katsumata, M., Gupta, C., Baker, M.K., Sussdorf, C.E., Goldman, A.S. Science (1982)
- Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate. Allen, R.W., Ogden, B., Bentley, F.L., Jung, A.L. JAMA (1980)
- Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. Tomaselli, G.F., Marban, E., Yellen, G. J. Clin. Invest. (1989)
- Diphenylhydantoin: action of a common anticonvulsant on bursting pacemaker cells in Aplysia. Johnston, D., Avala, G.F. Science (1975)
- Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gugler, R., Jensen, J.C. Gastroenterology (1985)
- Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy. de Silva, M., MacArdle, B., McGowan, M., Hughes, E., Stewart, J., Neville, B.G., Johnson, A.L., Reynolds, E.H. Lancet (1996)
- Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. Shimada, T., Misono, K.S., Guengerich, F.P. J. Biol. Chem. (1986)
- Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. Wang, H., Faucette, S., Moore, R., Sueyoshi, T., Negishi, M., LeCluyse, E. J. Biol. Chem. (2004)
- Osteogenic actions of phenytoin in human bone cells are mediated in part by TGF-beta 1. Nakade, O., Baylink, D.J., Lau, K.H. J. Bone Miner. Res. (1996)
- Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Donahue, S.R., Flockhart, D.A., Abernethy, D.R., Ko, J.W. Clin. Pharmacol. Ther. (1997)
- Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue, P., Banfield, C.R., Perhach, J.L., Mather, G.G., Racha, J.K., Levy, R.H. Clinical pharmacokinetics. (1997)
- Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. A paradox resolved. Surks, M.I., DeFesi, C.R. JAMA (1996)
- What to do about tic douloureux. Loeser, J.D. JAMA (1978)
- Removal of phenytoin by hemodialysis in uremic patients. Martin, E., Gambertoglio, J.G., Adler, D.S., Tozer, T.N., Roman, L.A., Grausz, H. JAMA (1977)