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Chemical Compound Review

Dilantin     5,5-diphenylimidazolidine- 2,4-dione

Synonyms: Epanutin, Fenitoin, Hydantol, Antisacer, Difenin, ...
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Disease relevance of Difenin


Psychiatry related information on Difenin

  • The patient had serious psychiatric problems; the ventricular premature beats were provoked by psychophysiologic stress, increased during REM sleep, were reduced by meditation, and were controlled by beta-adrenergic blockade, phenytoin and digitalization [6].
  • The Reynell language development scores followed a similar trend, with children exposed to phenytoin scoring significantly lower than their controls [7].
  • Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses [8].
  • Added improvement with phenytoin in scores on the Brief Psychiatric Rating Scale and Clinical Global Impression was seen in the patients with bipolar mania but not those with schizoaffective mania [9].
  • Comparison of KI values with mean brain levels of these drugs achieved during prevention of electroshock seizures indicates that diphenylhydantoin and carbamazepine occupy 35% and 50%, respectively, of their receptor sites associated with sodium channels at mean therapeutic concentrations [10].

High impact information on Difenin


Chemical compound and disease context of Difenin


Biological context of Difenin


Anatomical context of Difenin


Associations of Difenin with other chemical compounds


Gene context of Difenin


Analytical, diagnostic and therapeutic context of Difenin


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