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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Steroid-responsive tubular aggregate myopathy.

We report a man with an acute myalgia/cramp syndrome and tubular aggregates on his muscle biopsy. He was placed on prednisone and was found to be exquisitely sensitive to the drug, with changes of only 5 mg precipitating recurrence of symptoms. He was eventually tapered off all steroids, without symptoms, and repeat biopsy showed no tubular aggregates. We recommend similar patients be given a trial of high-dose steroids.[1]


  1. Steroid-responsive tubular aggregate myopathy. Gilchrist, J.M., Ambler, M., Agatiello, P. Muscle Nerve (1991) [Pubmed]
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