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Chemical Compound Review

AC1LCTU8     (8R,9R,10R,13R,14R,17S)-17- hydroxy-17-(2...

Synonyms: 1-Cortisone
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Disease relevance of prednisone


Psychiatry related information on prednisone


High impact information on prednisone


Chemical compound and disease context of prednisone


Biological context of prednisone

  • Eleven of 12 patients (92 percent) responded to prednisone with a mean threefold increase in the platelet count, resulting from increased platelet production (P less than 0.005); platelet survival was unchanged [21].
  • CONCLUSIONS: Treating women who have autoantibodies and recurrent fetal loss with prednisone and aspirin is not effective in promoting live birth, and it increases the risk of prematurity [22].
  • Measurement of forced vital capacity and forced expiratory volume in one second showed that there was no deterioration in the condition of patients in whom the dosage of prednisone was reduced [23].
  • The patients continued to receive prednisone (mean daily dose, 25 mg) and were randomly assigned to receive one infusion of immune globulin (2 g per kilogram of body weight) or placebo per month for three months, with the option of crossing over to the alternative therapy for three more months [24].
  • Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring [25].

Anatomical context of prednisone


Associations of prednisone with other chemical compounds


Gene context of prednisone

  • After a 1-wk course of prednisone, IL-2 expression was not altered in either group [36].
  • In contrast, after prednisone treatment, SR asthmatics had no significant change in either the number of BAL cells expressing mRNA for IL-4 or IL-5 [36].
  • Higher levels of MRP3 were found in patients with a poor in vivo response to prednisone, but this could not be confirmed in an independent case-control study (40 patients) for prednisone response [37].
  • However, inflammatory indices, which included the thickness of the lining cell layer and the density of the mononuclear cell infiltrate, were significantly higher in the RA patients treated with prednisone and those treated with MTX (P less than 0.05) [38].
  • Prednisone increases PGH-synthase 2 in atopic humans in vivo [39].

Analytical, diagnostic and therapeutic context of prednisone


  1. Long-term evaluation of chlorambucil plus prednisone in the idiopathic nephrotic syndrome of childhood. Williams, S.A., Makker, S.P., Ingelfinger, J.R., Grupe, W.E. N. Engl. J. Med. (1980) [Pubmed]
  2. Testicular function in boys after chemotherapy for acute lymphoblastic leukemia. Blatt, J., Poplack, D.G., Sherins, R.J. N. Engl. J. Med. (1981) [Pubmed]
  3. A controlled trial of corticosteroids in children with corrosive injury of the esophagus. Anderson, K.D., Rouse, T.M., Randolph, J.G. N. Engl. J. Med. (1990) [Pubmed]
  4. Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. McCune, W.J., Golbus, J., Zeldes, W., Bohlke, P., Dunne, R., Fox, D.A. N. Engl. J. Med. (1988) [Pubmed]
  5. Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin's lymphoma. Miller, T.P., Dahlberg, S., Cassady, J.R., Adelstein, D.J., Spier, C.M., Grogan, T.M., LeBlanc, M., Carlin, S., Chase, E., Fisher, R.I. N. Engl. J. Med. (1998) [Pubmed]
  6. A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group. Perrillo, R.P., Schiff, E.R., Davis, G.L., Bodenheimer, H.C., Lindsay, K., Payne, J., Dienstag, J.L., O'Brien, C., Tamburro, C., Jacobson, I.M. N. Engl. J. Med. (1990) [Pubmed]
  7. Failure of budesonide in a pilot study of treatment-dependent autoimmune hepatitis. Czaja, A.J., Lindor, K.D. Gastroenterology (2000) [Pubmed]
  8. A randomized controlled trial of prednisone in Alzheimer's disease. Koch, H.J., Szecsey, A. Neurology (2000) [Pubmed]
  9. Evidence that prednisone-induced myopathy is reversed by physical training. Horber, F.F., Scheidegger, J.R., Grünig, B.E., Frey, F.J. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  10. Myasthenia gravis in identical twins. Murphy, J., Murphy, S.F. Neurology (1986) [Pubmed]
  11. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. Schuh, S., Reisman, J., Alshehri, M., Dupuis, A., Corey, M., Arseneault, R., Alothman, G., Tennis, O., Canny, G. N. Engl. J. Med. (2000) [Pubmed]
  12. Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. Jones, J.W., Gruber, S.A., Barker, J.H., Breidenbach, W.C. N. Engl. J. Med. (2000) [Pubmed]
  13. Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis. Lai, H.C., FitzSimmons, S.C., Allen, D.B., Kosorok, M.R., Rosenstein, B.J., Campbell, P.W., Farrell, P.M. N. Engl. J. Med. (2000) [Pubmed]
  14. A controlled trial of exercise rehabilitation after heart transplantation. Kobashigawa, J.A., Leaf, D.A., Lee, N., Gleeson, M.P., Liu, H., Hamilton, M.A., Moriguchi, J.D., Kawata, N., Einhorn, K., Herlihy, E., Laks, H. N. Engl. J. Med. (1999) [Pubmed]
  15. Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy. Bartalena, L., Marcocci, C., Bogazzi, F., Manetti, L., Tanda, M.L., Dell'Unto, E., Bruno-Bossio, G., Nardi, M., Bartolomei, M.P., Lepri, A., Rossi, G., Martino, E., Pinchera, A. N. Engl. J. Med. (1998) [Pubmed]
  16. Relation between skin cancer and HLA antigens in renal-transplant recipients. Bouwes Bavinck, J.N., Vermeer, B.J., van der Woude, F.J., Vandenbroucke, J.P., Schreuder, G.M., Thorogood, J., Persijn, G.G., Claas, F.H. N. Engl. J. Med. (1991) [Pubmed]
  17. Prednisone and cyclosporine in the treatment of severe Graves' ophthalmopathy. Prummel, M.F., Mourits, M.P., Berghout, A., Krenning, E.P., van der Gaag, R., Koornneef, L., Wiersinga, W.M. N. Engl. J. Med. (1989) [Pubmed]
  18. A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. Kyle, R.A., Gertz, M.A., Greipp, P.R., Witzig, T.E., Lust, J.A., Lacy, M.Q., Therneau, T.M. N. Engl. J. Med. (1997) [Pubmed]
  19. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. Feagan, B.G., Rochon, J., Fedorak, R.N., Irvine, E.J., Wild, G., Sutherland, L., Steinhart, A.H., Greenberg, G.R., Gillies, R., Hopkins, M. N. Engl. J. Med. (1995) [Pubmed]
  20. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. Beck, R.W., Cleary, P.A., Anderson, M.M., Keltner, J.L., Shults, W.T., Kaufman, D.I., Buckley, E.G., Corbett, J.J., Kupersmith, M.J., Miller, N.R. N. Engl. J. Med. (1992) [Pubmed]
  21. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. Gernsheimer, T., Stratton, J., Ballem, P.J., Slichter, S.J. N. Engl. J. Med. (1989) [Pubmed]
  22. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. Laskin, C.A., Bombardier, C., Hannah, M.E., Mandel, F.P., Ritchie, J.W., Farewell, V., Farine, D., Spitzer, K., Fielding, L., Soloninka, C.A., Yeung, M. N. Engl. J. Med. (1997) [Pubmed]
  23. Methotrexate in the treatment of corticosteroid-dependent asthma. A double-blind crossover study. Mullarkey, M.F., Blumenstein, B.A., Andrade, W.P., Bailey, G.A., Olason, I., Wetzel, C.E. N. Engl. J. Med. (1988) [Pubmed]
  24. A controlled trial of high-dose intravenous immune globulin infusions as treatment for dermatomyositis. Dalakas, M.C., Illa, I., Dambrosia, J.M., Soueidan, S.A., Stein, D.P., Otero, C., Dinsmore, S.T., McCrosky, S. N. Engl. J. Med. (1993) [Pubmed]
  25. Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Reinisch, J.M., Simon, N.G., Karow, W.G., Gandelman, R. Science (1978) [Pubmed]
  26. T-lymphocyte--mediated granulopoietic failure. In vitro identification of prednisone-responsive patients. Bagby, G.C., Lawrence, H.J., Neerhout, R.C. N. Engl. J. Med. (1983) [Pubmed]
  27. Letter: Entry of prednisone into human milk. Katz, F.H., Duncan, B.R. N. Engl. J. Med. (1975) [Pubmed]
  28. Vestibular vertigo. A form of polyneuritis? Adour, K.K., Sprague, M.A., Hilsinger, R.L. JAMA (1981) [Pubmed]
  29. Cell-mediated immunity in acute and chronic hepatitis. Wands, J.R., Perrotto, J.L., Alpert, E., Isselbacher, K.J. J. Clin. Invest. (1975) [Pubmed]
  30. Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone. Dale, D.C., Fauci, A.S., Guerry D, I.V., Wolff, S.M. J. Clin. Invest. (1975) [Pubmed]
  31. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. Freed, C.R., Breeze, R.E., Rosenberg, N.L., Schneck, S.A., Kriek, E., Qi, J.X., Lone, T., Zhang, Y.B., Snyder, J.A., Wells, T.H. N. Engl. J. Med. (1992) [Pubmed]
  32. A randomized controlled trial of prednisone in patients with idiopathic membranous nephropathy. Cattran, D.C., Delmore, T., Roscoe, J., Cole, E., Cardella, C., Charron, R., Ritchie, S. N. Engl. J. Med. (1989) [Pubmed]
  33. High-dose intramuscular triamcinolone in severe, chronic, life-threatening asthma. Ogirala, R.G., Aldrich, T.K., Prezant, D.J., Sinnett, M.J., Enden, J.B., Williams, M.H. N. Engl. J. Med. (1991) [Pubmed]
  34. Prevention of acute graft rejection by the prostaglandin E1 analogue misoprostol in renal-transplant recipients treated with cyclosporine and prednisone. Moran, M., Mozes, M.F., Maddux, M.S., Veremis, S., Bartkus, C., Ketel, B., Pollak, R., Wallemark, C., Jonasson, O. N. Engl. J. Med. (1990) [Pubmed]
  35. Hepatoma in a child with methotrexate-induced hepatic fibrosis. Ruymann, F.B., Mosijczuk, A.D., Sayers, R.J. JAMA (1977) [Pubmed]
  36. Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. Leung, D.Y., Martin, R.J., Szefler, S.J., Sher, E.R., Ying, S., Kay, A.B., Hamid, Q. J. Exp. Med. (1995) [Pubmed]
  37. The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype. Steinbach, D., Wittig, S., Cario, G., Viehmann, S., Mueller, A., Gruhn, B., Haefer, R., Zintl, F., Sauerbrey, A. Blood (2003) [Pubmed]
  38. Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs. Haraoui, B., Pelletier, J.P., Cloutier, J.M., Faure, M.P., Martel-Pelletier, J. Arthritis Rheum. (1991) [Pubmed]
  39. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Dworski, R.T., Funk, C.D., Oates, J.A., Sheller, J.R. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  40. Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Robbins, W.A., Meistrich, M.L., Moore, D., Hagemeister, F.B., Weier, H.U., Cassel, M.J., Wilson, G., Eskenazi, B., Wyrobek, A.J. Nat. Genet. (1997) [Pubmed]
  41. Serum immunoglobulins in the nephrotic syndrome. A possible cause of minimal-change nephrotic syndrome. Giangiacomo, J., Cleary, T.G., Cole, B.R., Hoffsten, P., Robson, A.M. N. Engl. J. Med. (1975) [Pubmed]
  42. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. Bell, W.R., Braine, H.G., Ness, P.M., Kickler, T.S. N. Engl. J. Med. (1991) [Pubmed]
  43. A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group. Lewis, E.J., Hunsicker, L.G., Lan, S.P., Rohde, R.D., Lachin, J.M. N. Engl. J. Med. (1992) [Pubmed]
  44. A prospective, randomized, controlled trial of prednisone for dilated cardiomyopathy. Parrillo, J.E., Cunnion, R.E., Epstein, S.E., Parker, M.M., Suffredini, A.F., Brenner, M., Schaer, G.L., Palmeri, S.T., Cannon, R.O., Alling, D. N. Engl. J. Med. (1989) [Pubmed]
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