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Hyperchloremia and negative anion gap associated with polymyxin B administration.

A patient receiving polymyxin B sulfate intravenously for Gram-negative "anion gap". Both abnormalities resolved following discontinuation of the drug. In vitro investigation suggested that the electrolyte abnormalities resulted from the polycationic properties of polymyxin B.[1]

References

  1. Hyperchloremia and negative anion gap associated with polymyxin B administration. O'Connor, D.T., Stone, R.A. Arch. Intern. Med. (1978) [Pubmed]
 
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