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Lee, H.K. et al.

Propranolol:methacrylic acid copolymer binding interaction.

The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol.HCl to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.[1]

References

Propranolol:methacrylic acid copolymer binding interaction. Lee, H.K., Hajdu, J., McGoff, P. Journal of pharmaceutical sciences. (1991) [Pubmed]

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