Disease relevance of METHACRYLIC ACID

• While maternal toxicity was observed, methacrylic acid caused no evidence of developmental toxicity up to 300 ppm [1].
• Lichen planus-like contact dermatitis due to methacrylic acid esters [2].
• Anchorage independent human Burkitt lymphoma (Raji) cells were successfully cultured in the presence of dissolved MAA containing polymer [3].
• Hydrogel implants for urinary incontinence treatment based on HEMA supplemented with 10% methacrylic acid have been developed [4].
• As dental devices contain methacrylic acid esters, it is possible to speculate that methacrylic acid esters may be one of the causative agents for oral lichen planus [2].

Psychiatry related information on METHACRYLIC ACID

• Both the amount of MAA utilized in the preparation and reaction time affect the selectivity of chromatographic separation in both the HPLC and the CEC mode and electroosmotic flow [5].
• We used standard operant conditioning methods to train animals to discriminate low odor concentrations of D-carvone from clean air, to discriminate L-carvone from clean air; or to discriminate between clean air and the odors of D-carvone, L-carvone, ethyl acetate and methacrylic acid [6].

High impact information on METHACRYLIC ACID

• Pyrenemethylacetamidopenicillanic acid (PAAP) is the tagged antibiotic that provides the highest selectivity when competing with PenG for the specific binding sites in a MI polymer prepared with methacrylic acid and trimethylolpropane trimethacrylate (10:15 molar ratio) in acetonitrile in the presence of PenG [7].
• Nanoparticles, with an average diameter of 600 nm, were prepared by polymerization of methacrylic acid and trimethylolpropane trimethacrylate, which in turn were coated with dextran [8].
• A trimethylolpropane trimethacrylate-based monolith of dimensions carefully chosen to fit exactly in a standard 4-mm solid-state CP/MAS NMR rotor was photopolymerized and subsequently molecularly imprinted with bupivacaine using a grafting protocol with methacrylic acid and ethylene dimethacrylate as monomers [9].
• Methacrylic acid (MAA) and 2-(trifluoromethyl)acrylic acid (TFMAA) were used to prepare molecularly imprinted polymers exhibiting diastereoselectivity for cinchona alkaloids [10].
• Cells cultured on surfaces containing only methacrylic acid did not spread [11].

Chemical compound and disease context of METHACRYLIC ACID

• Furthermore, gavage administration of equimolar doses of methyl propionate or ethyl propionate (saturated analogues of methyl acrylate and ethyl acrylate, respectively) as well as methacrylic acid esters were without gastric toxicity [12].
• Pediatric poisonings from household products: hydrofluoric acid and methacrylic acid [13].

Biological context of METHACRYLIC ACID

• Hydrogen-bonding-based complexation of B-Me with MAA generates the binding sites complementary to B-Me after extracting B-Me from the resulting copolymers [14].
• Activation of prothrombin to alpha-thrombin generates not only the catalytic site and associated regions but also an independent site (an exosite) which binds anionic substances, such as Amberlite CG-50 resin [cross-linked poly(methylacrylic acid)] [15].
• Methacrylic acid (MAA), formed by hydrolysis of dex-HEMA, did not influence the cell morphology [16].
• Polymerization kinetics of binary formulations improved over pure PMMA (from 15 to 4 min) as a result of over a 60-fold increase in propagation-to-termination constants (Kp/Kt) of MAA/MMA [17].
• Bacterial adhesion on to copolymers with MAA was less than on to the corresponding homopolymers [18].

Anatomical context of METHACRYLIC ACID

• The membranes were prepared by radiation-grafting methacrylic acid and vinylpyridine to films of DuPont cellophane PD-215 to produce cation-exchange and anion-exchange membranes, respectively [19].
• These microcapsules of the functioning hepatocytes have a 2- to 3-microm outer layer of synthetic polymer with 25% 2-hydroxyethyl methacrylate, 25% methacrylic acid, and 50% methyl methacrylate and an inner layer of positively charged modified collagen as a suitable substrate for the enhanced cellular functions [20].
• There was no significant difference between cell nuclei density and coating for the four groups: uncoated, HF-coated, NN-coated, and MA-coated [21].
• This study was performed to identify the possible dental material intermediate 2,3-epoxymethacrylic acid (2,3-EMA) from MA in human liver microsomes [22].
• Novel methacrylic acid (MAA) copolymers were examined for their pH-sensitive properties and ability to destabilize cell membranes in a pH-dependent manner [23].

Associations of METHACRYLIC ACID with other chemical compounds

• Incorporation of the methacrylic acid polymer, Eudragit L100-55 resulted in marginal release enhancement as the pH modulation effected by this polymer was attenuated by the basicity of the drug [24].
• Copolymers of 2-hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) based hydrogels containing 5 and 10% of a cross-linking agent were studied as drug delivery systems [25].
• Theoretical study of the oxidation reactions of methylacrylic Acid and methyl methacrylate by triplet o(2) [26].
• MIP thin-layers with specific binding sites for S-propranolol were synthesized by copolymerization of methacrylic acid with a cross-linker, ethylene glycol dimethacrylate in the presence of S-propranolol as the template molecule and the latter was subsequently extracted [27].
• In the suspension polymerization technique used, polymers of methacrylic acid (MAA), highly cross-linked with ethylene dimethacrylate, provide a specific binding sites for the carbaryl molecule and its metabolite when using it as a template to be removed after polymerization [28].

Gene context of METHACRYLIC ACID

• Modification of Cys-418 of pyruvate formate-lyase by methacrylic acid, based on its radical mechanism [29].
• For composite materials containing a lightly cross-linked 2-hydroxyethylmethacrylate (HEMA)-methacrylic acid (MAA) copolymer and polymethacrylic acid (PMAA) as the hydrogel phase, permeability to water-soluble organic compounds and drugs were measured [30].
• In addition to the polymerized biomaterials, monomers containing methacrylic acid units were also hydrolyzed with esterase and analyzed by ion chromatography to establish the sensitivity of the enzyme simulator [31].
• Surfaces of copolymers with MAA had more negative zeta potentials than those of the corresponding homopolymers [18].
• The objective of the current study was to investigate the influence of TEGDMA derived degradation products MA and TEG on the growth of three strains of oral bacteria: S. mutans strains NG8 and JH1005, and S. salivarius AT2 [32].

Analytical, diagnostic and therapeutic context of METHACRYLIC ACID

• Data from NMR titration suggest a one-to-one prepolymerization complex formation of B-Me with MAA in chloroform [14].
• Microspheres were surface-modified by grafting methacrylic acid (MA) on to them using gamma-radiation from a Co60 source [33].
• The miscibility behaviour of blends of poly(styrene-co-methacrylic acide) (PSMA-12) containing 12% of methacrylic acid with poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) at five different compositions has been studied by inverse gas chromatography (IGC) [34].
• Following oral administration, only nanoparticles made of the methacrylic acid copolymer soluble at low pH provided sufficient plasma levels of CGP 57813 [35].
• Uniformly sized packing materials based on synthetic polymer particles for high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) have been prepared from polymerization mixtures containing methacrylic acid (MAA) as a functional monomer and by using a novel surface modification method [5].

References