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Helsby, N. et al.

Nuala Helsby, Michael Goldthorpe, Peter Gow, Janak de Zoysa,

Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?

AIM: To undertake a preliminary assessment of the prevalence of CYP2C19 ultra-rapid and poor metaboliser genetic variants in Pacific people compared with NZ Europeans. METHOD: Individuals who self-identified as either Pacific people (n=14) or NZ European (n=12) were genotyped for the *2, *3 or *17 functional variants of CYP2C19. RESULTS: There was a significantly lower frequency (P<0.01) of the CYP2C19*17 allele in Pacific people compared with NZ Europeans. No CYP2C19*17 variant alleles were detected in Pacific people in this preliminary study. CONCLUSIONS: The presence of CYP2C19*17 may be low in Pacific people and may lead to altered efficiency at metabolising some common drugs such as omeprazole. Further studies to confirm this preliminary finding are warranted.[1]

References

Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans? Helsby, N., Goldthorpe, M., Gow, P., de Zoysa, J. N. Z. Med. J. (2010) [Pubmed]

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