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MeSH Review

New Zealand

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Disease relevance of New Zealand


Psychiatry related information on New Zealand


High impact information on New Zealand

  • Data from a questionnaire regarding respiratory symptoms, plus measurements of the serum total IgE level and airway responsiveness to inhaled methacholine, were obtained for 562 11-year-olds in New Zealand. RESULTS [11].
  • Interestingly, this element can be spliced to C beta 2 in the New Zealand White mouse, in which the C beta 1 gene is deleted [12].
  • A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice [13].
  • 98% of sera completely neutralized SMEZ-1, but only 85% neutralized SMEZ-2, a very potent variant that has not yet been found in any New Zealand isolate [14].
  • New Zealand White (NZW) mice, with identical class II H-2u genes (I-A and I-E), carry an 8.8-kb deletion in their TCR beta chain locus encompassing D beta 2 and J beta 2 gene segments [15].

Chemical compound and disease context of New Zealand


Biological context of New Zealand


Anatomical context of New Zealand


Associations of New Zealand with chemical compounds


Gene context of New Zealand

  • In order to evaluate the extent to which the connexin 26 gene (Cx26) contributes to prelingual deafness, we searched for mutations in this gene in 65 affected Caucasian families originating from various countries, mainly tunisia, France, New Zealand and the UK [36].
  • Given the results of these previous studies, we examined whether the high incidence of sporadic colorectal cancer observed in New Zealand Caucasians was due to mutations within CARD15 [37].
  • Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice [38].
  • We have developed novel genetically lupus-prone (NZB x NZW)F(1)-derived congenic New Zealand mixed (NZM) 2328 lines, which are either Stat4- or Stat6-deficient [39].
  • Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice [39].

Analytical, diagnostic and therapeutic context of New Zealand


  1. Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism. Armstrong, J.M., Blackwell, G.J., Flower, R.J., McGiff, J.C., Mullane, K.M., Vane, J.R. Nature (1976) [Pubmed]
  2. Aerial spraying of 2,4,5-T and human birth malformations: an epidemiological investigation. Hanify, J.A., Metcalf, P., Nobbs, C.L., Worsley, K.J. Science (1981) [Pubmed]
  3. Lyme disease-a tick-borne spirochetosis? Burgdorfer, W., Barbour, A.G., Hayes, S.F., Benach, J.L., Grunwaldt, E., Davis, J.P. Science (1982) [Pubmed]
  4. Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone. Lucas, J.A., Ahmed, S.A., Casey, M.L., MacDonald, P.C. J. Clin. Invest. (1985) [Pubmed]
  5. Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment. Osborne, J.A., Lento, P.H., Siegfried, M.R., Stahl, G.L., Fusman, B., Lefer, A.M. J. Clin. Invest. (1989) [Pubmed]
  6. Predictive validity of categorically and dimensionally scored measures of disruptive childhood behaviors. Fergusson, D.M., Horwood, L.J. Journal of the American Academy of Child and Adolescent Psychiatry. (1995) [Pubmed]
  7. Maternal behavior in New Zealand white rabbits: quantification of somatic events, motor patterns, and steroid plasma levels. González-Mariscal, G., Díaz-Sánchez, V., Melo, A.I., Beyer, C., Rosenblatt, J.S. Physiol. Behav. (1994) [Pubmed]
  8. Potentiation in the neurotoxic induction of experimental chronic neurodegenerative disorders: N-butyl benzenesulfonamide and aluminum chloride. Strong, M.J., Garruto, R.M. Neurotoxicology (1991) [Pubmed]
  9. Disposition of SDZ ENA 713, an acetylcholinesterase inhibitor, in the rabbit. Habucky, K., Tse, F.L. Biopharmaceutics & drug disposition. (1998) [Pubmed]
  10. Molecular analysis of the Huntington's disease gene in New Zealand. Whitefield, J.E., Williams, L., Snow, K., Dixon, J., Winship, I., Stapleton, P.M., Faull, R.M., Love, D.R. N. Z. Med. J. (1996) [Pubmed]
  11. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. Sears, M.R., Burrows, B., Flannery, E.M., Herbison, G.P., Hewitt, C.J., Holdaway, M.D. N. Engl. J. Med. (1991) [Pubmed]
  12. Alternative splicing of murine T-cell receptor beta-chain transcripts. Behlke, M.A., Loh, D.Y. Nature (1986) [Pubmed]
  13. A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice. Kotzin, B.L., Barr, V.L., Palmer, E. Science (1985) [Pubmed]
  14. The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation. Proft, T., Moffatt, S.L., Weller, K.D., Paterson, A., Martin, D., Fraser, J.D. J. Exp. Med. (2000) [Pubmed]
  15. Holes in the T cell repertoire to myelin basic protein owing to the absence of the D beta 2-J beta 2 gene cluster: implications for T cell receptor recognition and autoimmunity. Kumar, V., Sercarz, E. J. Exp. Med. (1994) [Pubmed]
  16. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. Smith, A.H., Pearce, N.E., Fisher, D.O., Giles, H.J., Teague, C.A., Howard, J.K. J. Natl. Cancer Inst. (1984) [Pubmed]
  17. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Katsuya, T., Koike, G., Yee, T.W., Sharpe, N., Jackson, R., Norton, R., Horiuchi, M., Pratt, R.E., Dzau, V.J., MacMahon, S. Lancet (1995) [Pubmed]
  18. Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease. Reeves, W.C., Cunningham, D., Schwiter, E.J., Abt, A., Skarlatos, S., Wood, M.A., Whitesell, L. Circulation (1982) [Pubmed]
  19. Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia. Doppelt, S.H., Slovik, D.M., Neer, R.M., Nolan, J., Zusman, R.M., Potts, J.T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  20. Dose-intensive cyclophosphamide with etoposide and vincristine for pediatric solid tumors: a phase I/II pilot study by the Australia and New Zealand Childhood Cancer Study Group. White, L., McCowage, G., Kannourakis, G., Nayanar, V., Colnan, L., Kellie, S., Shaw, P., Seshadri, R., Lockwood, L., Tiedemann, K. J. Clin. Oncol. (1994) [Pubmed]
  21. Defects in antigen-specific immune tolerance in continuous B cell lines from autoimmune mice. Brooks, M.S., Aldo-Benson, M. J. Clin. Invest. (1986) [Pubmed]
  22. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Sears, M.R., Greene, J.M., Willan, A.R., Taylor, D.R., Flannery, E.M., Cowan, J.O., Herbison, G.P., Poulton, R. Lancet (2002) [Pubmed]
  23. A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. Rigby, R.J., Rozzo, S.J., Gill, H., Fernandez-Hart, T., Morley, B.J., Izui, S., Kotzin, B.L., Vyse, T.J. J. Immunol. (2004) [Pubmed]
  24. Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation. Wither, J.E., Lajoie, G., Heinrichs, S., Cai, Y.C., Chang, N., Ciofani, A., Cheung, Y.H., MacLeod, R. J. Immunol. (2003) [Pubmed]
  25. Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury. Brennan, D.C., Yui, M.A., Wuthrich, R.P., Kelley, V.E. J. Immunol. (1989) [Pubmed]
  26. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. Theofilopoulos, A.N., Eisenberg, R.A., Bourdon, M., Crowell, J.S., Dixon, F.J. J. Exp. Med. (1979) [Pubmed]
  27. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. Rossitch, E., Alexander, E., Black, P.M., Cooke, J.P. J. Clin. Invest. (1991) [Pubmed]
  28. Ricinoleic acid effect on the electrical activity of the small intestine in rabbits. Mathias, J.R., Martin, J.L., Burns, T.W., Carlson, G.M., Shields, R.P. J. Clin. Invest. (1978) [Pubmed]
  29. Species cross-reacting epithelial and urothelial specific antigens in human fetal, adult, and neoplastic bladder epithelium. Nathrath, W.B., Detheridge, F., Franks, L.M. J. Natl. Cancer Inst. (1979) [Pubmed]
  30. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Takeshita, S., Pu, L.Q., Stein, L.A., Sniderman, A.D., Bunting, S., Ferrara, N., Isner, J.M., Symes, J.F. Circulation (1994) [Pubmed]
  31. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70. Datta, S.K., McConahey, P.J., Manny, N., Theofilopoulos, A.N., Dixon, F.J., Schwartz, R.S. J. Exp. Med. (1978) [Pubmed]
  32. Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits. Xu, G., Salen, G., Shefer, S., Ness, G.C., Nguyen, L.B., Parker, T.S., Chen, T.S., Zhao, Z., Donnelly, T.M., Tint, G.S. J. Clin. Invest. (1995) [Pubmed]
  33. Proteases and oxidants in experimental pulmonary inflammatory injury. Schraufstätter, I.U., Revak, S.D., Cochrane, C.G. J. Clin. Invest. (1984) [Pubmed]
  34. Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. Shaish, A., Daugherty, A., O'Sullivan, F., Schonfeld, G., Heinecke, J.W. J. Clin. Invest. (1995) [Pubmed]
  35. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses. Smith, A.H., Patterson, D.G., Warner, M.L., MacKenzie, R., Needham, L.L. J. Natl. Cancer Inst. (1992) [Pubmed]
  36. Prelingual deafness: high prevalence of a 30delG mutation in the connexin 26 gene. Denoyelle, F., Weil, D., Maw, M.A., Wilcox, S.A., Lench, N.J., Allen-Powell, D.R., Osborn, A.H., Dahl, H.H., Middleton, A., Houseman, M.J., Dodé, C., Marlin, S., Boulila-ElGaïed, A., Grati, M., Ayadi, H., BenArab, S., Bitoun, P., Lina-Granade, G., Godet, J., Mustapha, M., Loiselet, J., El-Zir, E., Aubois, A., Joannard, A., Petit, C. Hum. Mol. Genet. (1997) [Pubmed]
  37. Caspase recruitment domain-containing protein 15 mutations in patients with colorectal cancer. Roberts, R.L., Gearry, R.B., Allington, M.D., Morrin, H.R., Robinson, B.A., Frizelle, F.A. Cancer Res. (2006) [Pubmed]
  38. Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice. Haraldsson, M.K., dela Paz, N.G., Kuan, J.G., Gilkeson, G.S., Theofilopoulos, A.N., Kono, D.H. J. Immunol. (2005) [Pubmed]
  39. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. Jacob, C.O., Zang, S., Li, L., Ciobanu, V., Quismorio, F., Mizutani, A., Satoh, M., Koss, M. J. Immunol. (2003) [Pubmed]
  40. Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons. Mitchel, J.F., Azrin, M.A., Fram, D.B., Hong, M.K., Wong, S.C., Barry, J.J., Bow, L.M., Curley, T.M., Kiernan, F.J., Waters, D.D. Circulation (1994) [Pubmed]
  41. Vitaxin, a humanized monoclonal antibody to the vitronectin receptor (alphavbeta3), reduces neointimal hyperplasia and total vessel area after balloon injury in hypercholesterolemic rabbits. Coleman, K.R., Braden, G.A., Willingham, M.C., Sane, D.C. Circ. Res. (1999) [Pubmed]
  42. Upregulation of estrogen receptor-alpha expression in rabbit cardiac allograft. Lou, H., Martin, M.B., Stoica, A., Ramwell, P.W., Foegh, M.L. Circ. Res. (1998) [Pubmed]
  43. Cytochrome P-450 isozyme LM3b from rabbit liver microsomes. Induction by triacetyloleandomycin purification and characterization. Bonfils, C., Dalet, C., Dalet-Beluche, I., Maurel, P. J. Biol. Chem. (1983) [Pubmed]
  44. Antibodies of restricted heterogeneity directed against the cardiac glycoside digoxin. Zurawski, V.R., Novotný, J., Haber, E., Margolies, M.N. J. Immunol. (1978) [Pubmed]
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