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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Change of intracellular calcium of neural cells induced by extracellular ATP.

Exposure of various neural cells to ATP increased intracellular Ca2+ and the production of inositol trisphosphate. The Ca2+ responses were also observed in the absence of extracellular Ca2+, suggesting that a part of Ca2+ mobilization took place from cytosolic storage. Since adenosine had no effect on intracellular Ca2+ increment, ATP appears to act through a P2- purinergic receptor. Islet-activating protein or pertussis toxin pretreatment hardly influenced the increase in intracellular Ca2+ and inositol trisphosphate production induced by ATP, suggesting that IAP-sensitive GTP-binding proteins do not play a practical role in this reaction.[1]

References

  1. Change of intracellular calcium of neural cells induced by extracellular ATP. Hirano, Y., Okajima, F., Tomura, H., Majid, M.A., Takeuchi, T., Kondo, Y. FEBS Lett. (1991) [Pubmed]
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