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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine.

Pain was induced in 19 healthy individuals by double-blind injections into the temporal muscle of 0.2 ml of physiological saline with or without active substances added. 5-Hydroxytryptamine (2 nmol) caused pain similar to saline, bradykinin (2 nmol) only insignificantly more pain (0.05 less than p less than 0.1), while a mixture of the two substances in half dosage (1 nmol + 1 nmol) caused pain significantly above saline (p less than 0.01). Variations in the response to saline did not permit a conclusion to be made on the question of induced tenderness. However, the mixture of the two substances appeared to lower the pressure-pain threshold as measured by a pressure algometer (p less than 0.05).[1]


  1. Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine. Jensen, K., Tuxen, C., Pedersen-Bjergaard, U., Jansen, I., Edvinsson, L., Olesen, J. Peptides (1990) [Pubmed]
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