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Chemical Compound Review

BRADYKININ     2-[[2-[[1-[2-[[2-[2-[[1-[1- [2-amino-5...

Synonyms: kinin 9, CHEMBL262419, BRS 640, PRS 640, LS-45210, ...
 
 
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Disease relevance of BRADYKININ

 

Psychiatry related information on BRADYKININ

 

High impact information on BRADYKININ

  • CONCLUSIONS: These data confirm that bradykinin contributes to the short-term effects of ACE inhibition on blood pressure in normotensive and hypertensive persons and suggest that bradykinin also contributes to the short-term effects of ACE inhibition on the renin-angiotensin system [11].
  • In this study, a specific bradykinin-receptor antagonist, icatibant acetate (HOE 140), was used to determine the contribution of bradykinin to the short-term effects of ACE inhibition on blood pressure and plasma renin activity in both normotensive and hypertensive subjects [11].
  • Desensitization of the kinase C pathway by prolonged exposure to phorbol abolished the induction of c-myc by subsequent phorbol challenge and attenuated c-myc induction by PDGF and bradykinin, but did not affect PDGF-stimulated mitogenesis [12].
  • HSDM1C1 cells possess a B2 bradykinin receptor, a type more sensitive to native bradykinin than to related peptides, including Met-Lys- and desArg9-bradykinin [2].
  • These data suggest that Hageman-factor fragments are potent hypotensive agents, presumably because they trigger the generation of bradykinin in recipients [13].
 

Chemical compound and disease context of BRADYKININ

 

Biological context of BRADYKININ

 

Anatomical context of BRADYKININ

  • In the vascular system, endothelium-derived relaxing factor (EDRF) is the name of the local hormone released from endothelial cells in response to vasodilators such as acetylcholine, bradykinin and histamine [23].
  • This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells [24].
  • In these cells bradykinin rapidly hydrolyses PtdIns(4,5)P2 to InsP3 and DG, raises intracellular Ca2+ and hyperpolarizes then depolarizes the cell membrane [25].
  • Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons [26].
  • Bradykinin significantly increased calcium levels in neurons co-cultured with astrocytes, but not in solitary neurons [27].
 

Associations of BRADYKININ with other chemical compounds

 

Gene context of BRADYKININ

 

Analytical, diagnostic and therapeutic context of BRADYKININ

References

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